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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
10
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pubmed:dateCreated |
2006-3-6
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pubmed:abstractText |
Prostate cancer is a major cause of cancer death and morbidity in western countries. However, because of its intrinsic nature of chemoresistance, there is only limited systemic therapy available for the patients. Vitamin E (VE) has been under intensive study as a chemopreventive agent for various types of cancers. Preclinical studies suggest that vitamin E succinate (VES) is the most effective antitumor analogue of VE, yet there are scarce studies of VES in prostate cancer. In this study, we investigated the effects of VES on a panel of prostate cancer cells, and a xenograft model of prostate cancer. Our results indicate that VES significantly inhibited proliferation and induced apoptosis of prostate cancer cell lines in a dose and time dependent manner. The results of microarray analysis followed by real-time RT-PCR and inhibitor analyses indicated that the VES-induced apoptosis is mediated by caspase-4 in prostate tumor cells. In our animal model of prostate cancer in SCID mouse, daily injection of VES significantly suppressed tumor growth as well as lung metastases. These results suggest a potential therapeutic utility of VES for patients with prostate cancer.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
May
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pubmed:issn |
0020-7136
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pubmed:author |
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pubmed:copyrightInfo |
Copyright (c) 2005 Wiley-Liss, Inc.
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
118
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2441-7
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16380976-Animals,
pubmed-meshheading:16380976-Apoptosis,
pubmed-meshheading:16380976-Caspases,
pubmed-meshheading:16380976-Caspases, Initiator,
pubmed-meshheading:16380976-Cell Proliferation,
pubmed-meshheading:16380976-Gene Expression Profiling,
pubmed-meshheading:16380976-Humans,
pubmed-meshheading:16380976-Male,
pubmed-meshheading:16380976-Mice,
pubmed-meshheading:16380976-Mice, SCID,
pubmed-meshheading:16380976-Oligonucleotide Array Sequence Analysis,
pubmed-meshheading:16380976-Prostatic Neoplasms,
pubmed-meshheading:16380976-Rats,
pubmed-meshheading:16380976-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16380976-Tocopherols,
pubmed-meshheading:16380976-Transplantation, Heterologous,
pubmed-meshheading:16380976-Tumor Cells, Cultured,
pubmed-meshheading:16380976-Vitamin E
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pubmed:year |
2006
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pubmed:articleTitle |
Vitamin E succinate suppresses prostate tumor growth by inducing apoptosis.
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pubmed:affiliation |
Division of GI Tumors, Department of Interdisciplinary Oncology, H. Lee Moffitt Cancer Center & Research Institute, Tampa, FL 33612, USA. malafamp@moffitt.usf.edu
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, Non-U.S. Gov't
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