Linked Life Data

16380757

Source:http://linkedlifedata.com/resource/pubmed/id/16380757

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2005-12-28
pubmed:abstractText
Because there is the impression that psoriatic arthritis is a composite disorder with mild forms close to more severe and aggressive ones, we conducted a multicenter study with the aim of characterizing disease expression in a large cohort of Italian patients. One-thousand-three-hundred-six patients fulfilled inclusion criteria and were analyzed in this study. Psoriasis antedated the onset of arthritis in the majority of the cases (67.7%). More rare was inverse or simultaneous onset which occurred in 17.3% and 15.0% of the cases, respectively. Peripheral articular involvement (mono-oligo or polyarthritis) was recorded in 88.7% of the cases while spondylitis occurred in 11.3%. Peripheral enthesopathies were found in 28.1% of the cases with a marked occurrence in patients with axial involvement (64.5% vs 35.5% in oligo or polyarthritis). Abnormal levels of ESR and CRP respectively occurred in 52.2% and in 52.6% of the cases, while rheumatoid factor was detected in 5.0% of the cases. On the basis of distribution of joint involvement, symmetry and presence of peripheral enthesopathies we recognized three clusters of arthritis. Patients included in Cluster 1 and Cluster 2 showed a severe form of polyarthritis in most of the cases (82.9%), with increased serum levels of inflammatory indices in more than 85% of the cases. Almost all the hospitalized patients (97.1%) were included in this two clusters. They markedly assumed steroids and methotrexate or another DMARD. About half of the patients (51.1%) included in Cluster 3 showed mono-oligo articular involvement. Serum inflammatory indices were increased in 20.8% of the cases while hospitalization occurred only in 2.9% of the cases and NSAIDs were the treatment of choice. The evidence in our country of a large prevalence of severe forms of arthritis needing specific and aggressive approach outlines the requirement of an intense educational action aimed at increasing the awareness of this condition.
pubmed:language
ita
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
0048-7449
pubmed:author
pubmed:issnType
Print
pubmed:volume
57
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
283-90
pubmed:meshHeading
pubmed-meshheading:16380757-Adult, pubmed-meshheading:16380757-Anti-Inflammatory Agents, Non-Steroidal, pubmed-meshheading:16380757-Antirheumatic Agents, pubmed-meshheading:16380757-Arthritis, Psoriatic, pubmed-meshheading:16380757-Biological Markers, pubmed-meshheading:16380757-Blood Sedimentation, pubmed-meshheading:16380757-C-Reactive Protein, pubmed-meshheading:16380757-Cluster Analysis, pubmed-meshheading:16380757-Cohort Studies, pubmed-meshheading:16380757-Diagnosis, Differential, pubmed-meshheading:16380757-Disease Progression, pubmed-meshheading:16380757-Drug Therapy, Combination, pubmed-meshheading:16380757-Female, pubmed-meshheading:16380757-Glucocorticoids, pubmed-meshheading:16380757-Humans, pubmed-meshheading:16380757-Italy, pubmed-meshheading:16380757-Male, pubmed-meshheading:16380757-Middle Aged, pubmed-meshheading:16380757-Predictive Value of Tests, pubmed-meshheading:16380757-Prevalence, pubmed-meshheading:16380757-Rheumatoid Factor, pubmed-meshheading:16380757-Severity of Illness Index, pubmed-meshheading:16380757-Treatment Outcome
pubmed:year
2005
pubmed:articleTitle
[Psoriatic arthritis: epidemiological and clinical aspects in a cohort of 1.306 Italian patients].
pubmed:affiliation
Clinica Reumatologica, Università di Ancona, Italia.
pubmed:publicationType
Journal Article, English Abstract, Multicenter Study