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rdf:type |
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lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0022116,
umls-concept:C0065337,
umls-concept:C0185117,
umls-concept:C0205145,
umls-concept:C0242629,
umls-concept:C0332448,
umls-concept:C0806987,
umls-concept:C0851285,
umls-concept:C0871261,
umls-concept:C1185727,
umls-concept:C1332714,
umls-concept:C1527148,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-4
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pubmed:abstractText |
Previous studies have demonstrated that macrophages and CD4+ T lymphocytes play pivotal roles in collateral development. Indirect evidence suggests that CD8+ T cells also play a role. Thus, after acute cerebral ischemia, CD8+ T cells infiltrate the perivascular space and secrete interleukin-16 (IL-16), a potent chemoattractant for monocytes and CD4+ T cells. We tested whether CD8+ T lymphocytes contribute to collateral vessel development and whether the lack of circulating CD8+ T cells prevents IL-16 expression, impairs CD4+ mononuclear cell recruitment, and reduces collateral vessel growth after femoral artery ligation in CD8(-/-) mice.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
pubmed-author:BurnettMary SusanMS,
pubmed-author:CampiaUmbertoU,
pubmed-author:EpsteinStephen ESE,
pubmed-author:FuchsShmuelS,
pubmed-author:HansonSue KimSK,
pubmed-author:KinnairdTimothyT,
pubmed-author:KornfeldHardyH,
pubmed-author:ShouMatieM,
pubmed-author:StabileEugenioE,
pubmed-author:WatkinsCraigC,
pubmed-author:ZbindenStephanS,
pubmed-author:la SalaAndreaA
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pubmed:issnType |
Electronic
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pubmed:day |
3
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pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
118-24
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pubmed:dateRevised |
2007-11-14
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pubmed:meshHeading |
pubmed-meshheading:16380545-Animals,
pubmed-meshheading:16380545-Antigens, CD8,
pubmed-meshheading:16380545-Arteriolosclerosis,
pubmed-meshheading:16380545-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16380545-CD8-Positive T-Lymphocytes,
pubmed-meshheading:16380545-Chemotaxis, Leukocyte,
pubmed-meshheading:16380545-Collateral Circulation,
pubmed-meshheading:16380545-Disease Models, Animal,
pubmed-meshheading:16380545-Femoral Artery,
pubmed-meshheading:16380545-Immune System,
pubmed-meshheading:16380545-Interleukin-16,
pubmed-meshheading:16380545-Ischemia,
pubmed-meshheading:16380545-Mice,
pubmed-meshheading:16380545-Mice, Knockout
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pubmed:year |
2006
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pubmed:articleTitle |
CD8+ T lymphocytes regulate the arteriogenic response to ischemia by infiltrating the site of collateral vessel development and recruiting CD4+ mononuclear cells through the expression of interleukin-16.
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pubmed:affiliation |
Cardiovascular Research Institute, MedStar Research Institute, Washington Hospital Center, Washington, DC 20010, USA. geko50@tiscali.it
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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