rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-4
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pubmed:abstractText |
Meta-analyses predict that a 25% lowering of plasma homocysteine would reduce the risk of coronary heart disease by 11% to 16% and stroke by 19% to 24%. Individuals homozygous for the methylenetetrahydrofolate reductase (MTHFR) 677C-->T polymorphism have reduced MTHFR enzyme activity resulting from the inappropriate loss of the riboflavin cofactor, but it is unknown whether their typically high homocysteine levels are responsive to improved riboflavin status.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1524-4539
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
3
|
pubmed:volume |
113
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
74-80
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16380544-Adolescent,
pubmed-meshheading:16380544-Adult,
pubmed-meshheading:16380544-Aged,
pubmed-meshheading:16380544-Coronary Disease,
pubmed-meshheading:16380544-Dietary Supplements,
pubmed-meshheading:16380544-Drug Evaluation,
pubmed-meshheading:16380544-Europe,
pubmed-meshheading:16380544-Homocysteine,
pubmed-meshheading:16380544-Homozygote,
pubmed-meshheading:16380544-Humans,
pubmed-meshheading:16380544-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:16380544-Middle Aged,
pubmed-meshheading:16380544-North America,
pubmed-meshheading:16380544-Polymorphism, Single Nucleotide,
pubmed-meshheading:16380544-Riboflavin
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pubmed:year |
2006
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pubmed:articleTitle |
Riboflavin lowers homocysteine in individuals homozygous for the MTHFR 677C->T polymorphism.
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pubmed:affiliation |
Northern Ireland Centre for Food and Health, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland. h.mcnulty@ulster.ac.uk
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pubmed:publicationType |
Journal Article,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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