Linked Life Data

16380474

Source:http://linkedlifedata.com/resource/pubmed/id/16380474

Statements in which the resource exists.
SubjectPredicateObjectContext
pubmed-article:16380474rdf:typepubmed:Citationlld:pubmed
pubmed-article:16380474lifeskim:mentionsumls-concept:C0026809lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C0023884lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C0450127lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C2350466lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C0035015lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C1882923lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C1548437lld:lifeskim
pubmed-article:16380474lifeskim:mentionsumls-concept:C0522536lld:lifeskim
pubmed-article:16380474pubmed:issue1lld:pubmed
pubmed-article:16380474pubmed:dateCreated2005-12-28lld:pubmed
pubmed-article:16380474pubmed:abstractTextA role of natural killer T (NKT) cells in transplant rejection remains unknown. Here, we determined whether NKT cells participate in rejection of islet allografts, using NKT cell-deficient mice. Survival of islet allografts in streptozotocin-induced diabetic CD1d(-/-) mice or Valpha14 NKT cell(-/-) mice was significantly prolonged without immunosuppression when grafted into the liver, but not beneath the kidney capsule, compared with wild-type mice. Acceptance of intrahepatic islet allografts was achieved in CD1d(-/-) mice by a subtherapeutic dose of rapamycin, which was abrogated in conjunction with the transfer of hepatic mononuclear cells from wild-type, but not from CD1d(-/-), mice at islet transplantation. The second islet grafts from a donor-specific, but not from a third-party, strain in CD1d(-/-) mice bearing functional islet allografts were accepted without immunosuppression at 120 days after the initial transplantation. These findings demonstrate that NKT cells play a significant role in rejection of islet allografts in the liver of mice, but that NKT cells are not essential for induction of donor-specific unresponsiveness in this model. The current study indicates that NKT cells might be considered as a target for intervention to prevent islet allograft rejection when the liver is the site of transplantation.lld:pubmed
pubmed-article:16380474pubmed:languageenglld:pubmed
pubmed-article:16380474pubmed:journalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380474pubmed:citationSubsetAIMlld:pubmed
pubmed-article:16380474pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380474pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380474pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380474pubmed:chemicalhttp://linkedlifedata.com/r...lld:pubmed
pubmed-article:16380474pubmed:statusMEDLINElld:pubmed
pubmed-article:16380474pubmed:monthJanlld:pubmed
pubmed-article:16380474pubmed:issn0012-1797lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:NakayamaToshi...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:TaniguchiMasa...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:TanakaMasaoMlld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:OnoJunkoJlld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:SatohMasayuki...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:IkedaSeiyoSlld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:YasunamiYohic...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:NakanoMasahik...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:NabeyamaKenta...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:ToyofukuAtsus...lld:pubmed
pubmed-article:16380474pubmed:authorpubmed-author:MatsuokaNobuh...lld:pubmed
pubmed-article:16380474pubmed:issnTypePrintlld:pubmed
pubmed-article:16380474pubmed:volume55lld:pubmed
pubmed-article:16380474pubmed:ownerNLMlld:pubmed
pubmed-article:16380474pubmed:authorsCompleteYlld:pubmed
pubmed-article:16380474pubmed:pagination34-9lld:pubmed
pubmed-article:16380474pubmed:dateRevised2008-11-21lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:meshHeadingpubmed-meshheading:16380474...lld:pubmed
pubmed-article:16380474pubmed:year2006lld:pubmed
pubmed-article:16380474pubmed:articleTitleNatural killer T-cells participate in rejection of islet allografts in the liver of mice.lld:pubmed
pubmed-article:16380474pubmed:affiliationDepartment of Surgery I, Fukuoka University School of Medicine, 7-45-1 Nanakuma, Jonan-ku, Fukuoka 814-0180, Japan.lld:pubmed
pubmed-article:16380474pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:16380474pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380474lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380474lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380474lld:pubmed
http://linkedlifedata.com/r...pubmed:referesTopubmed-article:16380474lld:pubmed