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rdf:type |
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lifeskim:mentions |
umls-concept:C0016030,
umls-concept:C0026538,
umls-concept:C0030705,
umls-concept:C0034537,
umls-concept:C0040690,
umls-concept:C0043240,
umls-concept:C0080103,
umls-concept:C0332293,
umls-concept:C0334094,
umls-concept:C0441655,
umls-concept:C0445204,
umls-concept:C1123023,
umls-concept:C1420490,
umls-concept:C1516240,
umls-concept:C1522449,
umls-concept:C1533691
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pubmed:issue |
1
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pubmed:dateCreated |
2006-1-27
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pubmed:abstractText |
In a recent study, we demonstrated that the ability of dermal fibroblasts, obtained from soft tissue sarcoma (STS) patients, to undergo initial division in vitro following radiation exposure correlated with the development of wound healing morbidity in the patients following their treatment with preoperative radiotherapy. Transforming growth factor beta (TGF-beta) is thought to play an important role in fibroblast proliferation and radiosensitivity both of which may impact on wound healing. Thus, in this study we examined the interrelationship between TGF-beta activity, radiosensitivity and proliferation of cultured fibroblasts and the wound healing response of STS patients after preoperative radiotherapy to provide a validation cohort for our previous study and to investigate mechanisms.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0167-8140
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
78
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-26
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16380182-Adolescent,
pubmed-meshheading:16380182-Adult,
pubmed-meshheading:16380182-Aged,
pubmed-meshheading:16380182-Aged, 80 and over,
pubmed-meshheading:16380182-Cell Nucleus,
pubmed-meshheading:16380182-Cell Proliferation,
pubmed-meshheading:16380182-Cells, Cultured,
pubmed-meshheading:16380182-Female,
pubmed-meshheading:16380182-Fibroblasts,
pubmed-meshheading:16380182-Humans,
pubmed-meshheading:16380182-Linear Models,
pubmed-meshheading:16380182-Male,
pubmed-meshheading:16380182-Middle Aged,
pubmed-meshheading:16380182-Preoperative Care,
pubmed-meshheading:16380182-Radiation Tolerance,
pubmed-meshheading:16380182-Regression Analysis,
pubmed-meshheading:16380182-Sarcoma,
pubmed-meshheading:16380182-Skin,
pubmed-meshheading:16380182-Soft Tissue Neoplasms,
pubmed-meshheading:16380182-Transforming Growth Factor beta,
pubmed-meshheading:16380182-Wound Healing
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pubmed:year |
2006
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pubmed:articleTitle |
Wound healing morbidity in STS patients treated with preoperative radiotherapy in relation to in vitro skin fibroblast radiosensitivity, proliferative capacity and TGF-beta activity.
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pubmed:affiliation |
Division of Applied Molecular Oncology, Ontario Cancer Institute/Princess Margaret Hospital, Toronto, Ont., Canada.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Validation Studies
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