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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1975-6-9
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pubmed:abstractText |
Sixty-nine strains of Clostridium perfringens of different toxigenic types were investigated for enterotoxin production. Enterotoxin was definitively detected only in strains of types A and C. This is the first report where enterotoxin production has been demonstrated in a toxigenic type other than type A. The exterotoxin-positive type C strains were isolated from cases of enteritis necroticans ("pig bel+) in New Guinea. The major enterotoxin from type C showed a reaction of complete identity with enterotoxin from type A in immunodiffusion using anti-enterotoxin serum prepared against the latter; it induced erythema when injected intradermally into depilated guinea pigs and caused fluid accumulation in the rabbit ileal loop. The results indicate that the major enterotoxin from type C was serologically and biologically similar to enterotoxin from type A. In some C was serologically and biologically similar to enterotoxin from type A. In some type C strains, an enterotoxin was detected that showed a reaction of partial serological identity. Spore coat proteins were extracted from 14-strains by alkaline dithiothreitol, and the extracts were assayed for enterotoxin-like spore protein. Enterotoxin could be extracted from type A and type C spores, and all positive strains showed a reaction of complete identity in immunodiffusion with enterotoxin obtained from cell extracts of type A. Disc immunoelectrophoresis demonstrated that two distinct components that reacted serologically with anti-enterotoxin serum were present in both the cell extract and in extracted spore protein from one type C strain. These distinct components differed in molecular weight.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-13044934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-13044935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-13319269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-13861594,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-13936795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-14194989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-14907713,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-16560992,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-18109335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4119831,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4288244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4295179,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4310083,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4324195,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4333491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4333607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4336110,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4343403,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4344364,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4344960,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4347930,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4350345,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4356461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/163799-4359628
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0019-9567
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
563-75
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:163799-Animals,
pubmed-meshheading:163799-Bacterial Proteins,
pubmed-meshheading:163799-Bacteriological Techniques,
pubmed-meshheading:163799-Clostridium perfringens,
pubmed-meshheading:163799-Electrophoresis, Disc,
pubmed-meshheading:163799-Enterotoxins,
pubmed-meshheading:163799-Hemagglutination Tests,
pubmed-meshheading:163799-Ileum,
pubmed-meshheading:163799-Immune Sera,
pubmed-meshheading:163799-Immunodiffusion,
pubmed-meshheading:163799-Microscopy, Electron,
pubmed-meshheading:163799-Microscopy, Phase-Contrast,
pubmed-meshheading:163799-Molecular Weight,
pubmed-meshheading:163799-Rabbits,
pubmed-meshheading:163799-Spores, Bacterial,
pubmed-meshheading:163799-Tissue Extracts
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pubmed:year |
1975
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pubmed:articleTitle |
Enterotoxin formation by different toxigenic types of Clostridium perfringens.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, U.S. Gov't, Non-P.H.S.
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