Linked Life Data

1637794

Source:http://linkedlifedata.com/resource/pubmed/id/1637794

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
8
pubmed:dateCreated
1992-9-1
pubmed:abstractText
We have conducted a crossover, randomized, double-blind dietary trial that tested the hypothesis that gender influences the response of plasma lipids, in particular high density lipoprotein (HDL) cholesterol, to dietary fat plus cholesterol. Twenty-six men and 25 women were matched for age, low density lipoprotein (LDL) cholesterol, triglyceride, and body mass index (BMI). After a 2-week baseline low-fat (27% of calories), low-cholesterol period, subjects were given two isocaloric liquid supplements for 3 weeks each, one containing 31 g fat (56% saturated) and 650 mg cholesterol, and the other fat free. The baseline HDL2 cholesterol level was significantly higher in women: 0.41 versus 0.26 mmol/l (p less than 0.01). Importantly, women also showed a greater rise in HDL2 cholesterol concentration with the fat/cholesterol supplement: 0.09 versus 0.03 mmol/l (p less than 0.01). The greater increment in women was related to their higher baseline HDL2 cholesterol levels. With the fat and cholesterol supplement, LDL cholesterol values rose from 3.76 to 4.04 mmol/l in women and from 3.77 to 4.13 mmol/l in men. The baseline LDL cholesterol value was found to account for about 35% of the variance in the rise in LDL cholesterol level with fat and cholesterol supplementation in both men and women less than 50 years. In men only, there was a significant effect of age: the change in LDL cholesterol with the fat/cholesterol supplement was 0.16 mmol/l in those less than 50 and 0.54 mmol/l in those greater than 50 years old (p less than 0.01).(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Aug
pubmed:issn
1049-8834
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
955-62
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1992
pubmed:articleTitle
Influence of gender, body mass index, and age on response of plasma lipids to dietary fat plus cholesterol.
pubmed:affiliation
CSIRO, Division of Human Nutrition, Adelaide, South Australia.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial, Research Support, Non-U.S. Gov't