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Predicate | Object |
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rdf:type | |
lifeskim:mentions |
umls-concept:C0001554,
umls-concept:C0006826,
umls-concept:C0021745,
umls-concept:C0022702,
umls-concept:C0030705,
umls-concept:C0178602,
umls-concept:C0205263,
umls-concept:C0205463,
umls-concept:C0302350,
umls-concept:C0439857,
umls-concept:C0871261,
umls-concept:C1522405,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C1707520,
umls-concept:C2911692
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pubmed:issue |
1
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pubmed:dateCreated |
1992-8-31
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pubmed:abstractText |
The administration of recombinant interleukin-2 as an i.v. bolus at dose levels of from 1 to 30 MIU/m2 to patients with cancer induces easily measurable serum interferon-gamma levels of 1 to 500 U/ml. After a lag of 1 h, interferon-gamma rises to a maximum at 4 h and then slowly decreases. The peak values are poorly correlated with the dose of interleukin-2, and thus must be also be dependent on other factors. Successive administration of interleukin-2 typically increases the peak level of interferon-gamma fourfold, but does not diminish the lag period. Peak levels of interferon-gamma are also increased by concurrent administration of interferon-beta with interleukin-2. Continuous i.v. infusion of 1.5 to 20 MIU/m2 of interleukin-2/day results in interferon-gamma levels of 1 to 7 U/ml. Hypotension, which is characteristically associated with interleukin-2 administration, is correlated with interferon-gamma levels in only some patients. There was no apparent correlation between tumor regression and serum interferon-gamma levels.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
1053-8550
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
55-63
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:1637783-Blood Pressure,
pubmed-meshheading:1637783-Dose-Response Relationship, Drug,
pubmed-meshheading:1637783-Humans,
pubmed-meshheading:1637783-Infusions, Intravenous,
pubmed-meshheading:1637783-Injections, Intravenous,
pubmed-meshheading:1637783-Interferon Inducers,
pubmed-meshheading:1637783-Interferon-gamma,
pubmed-meshheading:1637783-Interleukin-2,
pubmed-meshheading:1637783-Kinetics,
pubmed-meshheading:1637783-Neoplasms,
pubmed-meshheading:1637783-Radioimmunoassay,
pubmed-meshheading:1637783-Recombinant Proteins
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pubmed:year |
1992
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pubmed:articleTitle |
Interferon-gamma induced by administration of recombinant interleukin-2 to patients with cancer: kinetics, dose dependence, and correlation with physiological and therapeutic response.
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pubmed:affiliation |
de Vlaminck Institute, Lafayette, California.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study
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