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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-26
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pubmed:abstractText |
A macrolide-resistant clinical isolate of Streptococcus pneumoniae with 23S rRNA mutations showed a heterogeneous phenotype and genotype. The mutant 23S rRNA genes from this isolate transformed susceptible strain R6 to resistance. Culture of resistant strain R6 in the absence of antibiotic pressure showed gene conversion to occur between the four 23S rRNA alleles, resulting in reversion to susceptibility with the resistant phenotype showing a fitness cost. These data explain the disappearance on subculture of heterogeneous macrolide resistance in the pneumococcus.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-10049249,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-10898684,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-10990264,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11036030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11040282,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11083646,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11120994,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11125085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11302838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-11751122,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-12234875,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-12447736,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-12533472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-12760848,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-14171462,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-14506047,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-15347637,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-16048983,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-7793855,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-8239609,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-8843287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/16377711-8913465
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0066-4804
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
50
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
359-61
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:16377711-Anti-Bacterial Agents,
pubmed-meshheading:16377711-Drug Resistance, Bacterial,
pubmed-meshheading:16377711-Gene Conversion,
pubmed-meshheading:16377711-Humans,
pubmed-meshheading:16377711-Macrolides,
pubmed-meshheading:16377711-Pneumococcal Infections,
pubmed-meshheading:16377711-RNA, Bacterial,
pubmed-meshheading:16377711-RNA, Ribosomal, 23S,
pubmed-meshheading:16377711-Streptococcus pneumoniae
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pubmed:year |
2006
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pubmed:articleTitle |
Heterogeneous macrolide resistance and gene conversion in the pneumococcus.
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pubmed:affiliation |
Respiratory and Meningeal Pathogens Research Unit, National Institute for Communicable Diseases, Private Bag X4, Sandringham, 2131, South Africa. nicolew@nicd.ac.za
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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