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rdf:type |
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lifeskim:mentions |
umls-concept:C0001041,
umls-concept:C0013030,
umls-concept:C0021469,
umls-concept:C0030685,
umls-concept:C0086418,
umls-concept:C0206128,
umls-concept:C0391871,
umls-concept:C0680255,
umls-concept:C1283071,
umls-concept:C1519355,
umls-concept:C1880022,
umls-concept:C1963578
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pubmed:issue |
5
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pubmed:dateCreated |
2005-12-26
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pubmed:abstractText |
The autoinhibitory control of electrically evoked release of [3H]-dopamine and the properties of that induced by nicotinic receptor (nAChR) stimulation were studied in slices of the human neocortex. In both models [3H]-dopamine release was action potential-induced and exocytotic. The selective dopamine D2 receptor agonist (-)-quinpirole reduced electrically evoked release of [3H]-dopamine, yielding IC50 and I(max) values of 23 nM and 76%, respectively. Also, the effects of several other subtype-selective dopamine receptor ligands confirmed that the terminal dopamine autoreceptor belongs to the D2 subtype. The autoinhibitory feedback control was slightly operative under stimulation conditions of 90 pulses and 3 Hz, with a biophase concentration of endogenous dopamine of 3.6 nM, and was enhanced under blockade of dopamine reuptake. [3H]-dopamine release evoked in an identical manner in mouse neocortical slices was not inhibited by (-)-quinpirole, suggesting the absence of dopamine autoreceptors in this tissue and underlining an important species difference. Also, nAChR stimulation-induced release of [3H]-dopamine revealed a species difference: [3H]-dopamine release was evoked in human, but not in rat neocortical slices. The nAChRs inducing [3H]-dopamine release most probably belong to the alpha3/beta2subtype, according to the potencies and efficacies of subtype-selective nAChR ligands. Part of these receptors may be located on glutamatergic neurons.
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pubmed:grant |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/1,2,3,6-tetrahydro-4-phenyl-1-((3-ph...,
http://linkedlifedata.com/resource/pubmed/chemical/1-Methyl-4-phenyl-1,2,3,6-tetrahydro...,
http://linkedlifedata.com/resource/pubmed/chemical/3-methyl-5-(1-methyl-2-pyrrolidinyl)...,
http://linkedlifedata.com/resource/pubmed/chemical/Alkaloids,
http://linkedlifedata.com/resource/pubmed/chemical/Autoreceptors,
http://linkedlifedata.com/resource/pubmed/chemical/Azocines,
http://linkedlifedata.com/resource/pubmed/chemical/Calcium,
http://linkedlifedata.com/resource/pubmed/chemical/Domperidone,
http://linkedlifedata.com/resource/pubmed/chemical/Dopamine Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fluvoxamine,
http://linkedlifedata.com/resource/pubmed/chemical/Isoxazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Maprotiline,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotine,
http://linkedlifedata.com/resource/pubmed/chemical/Nicotinic Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Potassium,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrrolidines,
http://linkedlifedata.com/resource/pubmed/chemical/Quinolizines,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Nicotinic,
http://linkedlifedata.com/resource/pubmed/chemical/Sulpiride,
http://linkedlifedata.com/resource/pubmed/chemical/Tritium,
http://linkedlifedata.com/resource/pubmed/chemical/cytisine,
http://linkedlifedata.com/resource/pubmed/chemical/hydroxymaprotilin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0361-9230
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
30
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pubmed:volume |
68
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
361-73
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pubmed:dateRevised |
2011-9-22
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pubmed:meshHeading |
pubmed-meshheading:16377444-1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine,
pubmed-meshheading:16377444-Adolescent,
pubmed-meshheading:16377444-Adult,
pubmed-meshheading:16377444-Aged,
pubmed-meshheading:16377444-Alkaloids,
pubmed-meshheading:16377444-Analysis of Variance,
pubmed-meshheading:16377444-Animals,
pubmed-meshheading:16377444-Autoreceptors,
pubmed-meshheading:16377444-Azocines,
pubmed-meshheading:16377444-Calcium,
pubmed-meshheading:16377444-Child,
pubmed-meshheading:16377444-Child, Preschool,
pubmed-meshheading:16377444-Domperidone,
pubmed-meshheading:16377444-Dopamine,
pubmed-meshheading:16377444-Dopamine Antagonists,
pubmed-meshheading:16377444-Dose-Response Relationship, Drug,
pubmed-meshheading:16377444-Drug Interactions,
pubmed-meshheading:16377444-Electric Stimulation,
pubmed-meshheading:16377444-Feedback,
pubmed-meshheading:16377444-Female,
pubmed-meshheading:16377444-Fluvoxamine,
pubmed-meshheading:16377444-Humans,
pubmed-meshheading:16377444-Isoxazoles,
pubmed-meshheading:16377444-Male,
pubmed-meshheading:16377444-Maprotiline,
pubmed-meshheading:16377444-Mice,
pubmed-meshheading:16377444-Middle Aged,
pubmed-meshheading:16377444-Neocortex,
pubmed-meshheading:16377444-Nicotine,
pubmed-meshheading:16377444-Nicotinic Antagonists,
pubmed-meshheading:16377444-Potassium,
pubmed-meshheading:16377444-Pyrrolidines,
pubmed-meshheading:16377444-Quinolizines,
pubmed-meshheading:16377444-Rats,
pubmed-meshheading:16377444-Receptors, Nicotinic,
pubmed-meshheading:16377444-Sulpiride,
pubmed-meshheading:16377444-Time Factors,
pubmed-meshheading:16377444-Tritium
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pubmed:year |
2006
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pubmed:articleTitle |
Dopamine release in human neocortical slices: characterization of inhibitory autoreceptors and of nicotinic acetylcholine receptor-evoked release.
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