Linked Life Data

16377261

Source:http://linkedlifedata.com/resource/pubmed/id/16377261

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
2006-9-25
pubmed:abstractText
The aim of the study was to determine whether a decrease in the ventilatory response to carbon dioxide (CO2) in children with cystic fibrosis (CF) is related to a mechanical limitation of the respiratory muscle capacity. The ventilatory response during CO2 rebreathing was performed in 15 patients (mean forced expiratory volume in 1 s (FEV1): 37 +/- 21% predicted, mean arterial CO2: 41+/- 5 mmHg). The slope of the minute ventilation normalised for weight per mmHg CO2 increment correlated negatively with respiratory muscle output, assessed by the oesophageal (p = 0.002), the diaphragmatic pressure time product (p = 0.01), and the tension time index (p = 0.005). In addition, this slope was correlated with dynamic lung compliance (p < 0.0001) and FEV1 (p = 0.03) but not with airway resistance and maximal transdiaphragmatic pressure. Therefore, an excessive load imposed on the respiratory muscles explains the blunting of the ventilatory response to CO2 in young patients with CF.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1569-9048
pubmed:author
pubmed:issnType
Print
pubmed:day
27
pubmed:volume
153
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
217-25
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Mechanical limitation during CO2 rebreathing in young patients with cystic fibrosis.
pubmed:affiliation
Pediatric Pulmonary Department, Armand Trousseau Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France. Brigitte.fauroux@trs.ap-hop-paris.fr
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't