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| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C1415341 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C1719914 | lld:lifeskim |
| pubmed-article:16376852 | lifeskim:mentions | umls-concept:C2828406 | lld:lifeskim |
| pubmed-article:16376852 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:16376852 | pubmed:dateCreated | 2006-1-13 | lld:pubmed |
| pubmed-article:16376852 | pubmed:abstractText | Western blot analysis of 3T3-L1 adipocyte proteins using an anti-C/EBPalpha antibody detected a 24kD polypeptide in addition to the expected 42 and 30kD isoforms of C/EBPalpha. Mass spectrometric sequencing of the protein following its purification by HPLC and preparative 2D gel electrophoresis identified it as glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI). Expression of GSTzeta/MAAI mRNA and protein was induced during the terminal phase of adipogenesis in 3T3-L1 preadipocytes. Ectopic expression of PPARgamma2 in NIH-3T3 fibroblasts exposed to insulin and troglitazone-induced perilipin production, but was incapable of activating GSTzeta/MAAI unless C/EBPalpha was also expressed. Similarly, ectopic expression of C/EBPalpha in PPARgamma +/- or PPARgamma -/- MEFs demonstrated that the C/EBPalpha-dependent induction of GSTzeta/MAAI production was dependent on expression of endogenous PPARgamma. These data suggest a role for GSTzeta/MAAI in mature adipocytes that may be responsive to the thiazolidinedione class of insulin sensitizing PPARgamma ligands. | lld:pubmed |
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| pubmed-article:16376852 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:16376852 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:16376852 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16376852 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:16376852 | pubmed:issn | 0006-291X | lld:pubmed |
| pubmed-article:16376852 | pubmed:author | pubmed-author:LiQiangQ | lld:pubmed |
| pubmed-article:16376852 | pubmed:author | pubmed-author:FarmerStephen... | lld:pubmed |
| pubmed-article:16376852 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16376852 | pubmed:day | 17 | lld:pubmed |
| pubmed-article:16376852 | pubmed:volume | 340 | lld:pubmed |
| pubmed-article:16376852 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16376852 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16376852 | pubmed:pagination | 845-51 | lld:pubmed |
| pubmed-article:16376852 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:16376852 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16376852 | pubmed:articleTitle | C/EBPalpha-dependent induction of glutathione S-transferase zeta/maleylacetoacetate isomerase (GSTzeta/MAAI) expression during the differentiation of mouse fibroblasts into adipocytes. | lld:pubmed |
| pubmed-article:16376852 | pubmed:affiliation | Department of Biochemistry, Boston University School of Medicine, Boston, MA 02118, USA. | lld:pubmed |
| pubmed-article:16376852 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16376852 | pubmed:publicationType | Research Support, N.I.H., Extramural | lld:pubmed |
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