Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-23
pubmed:abstractText
We have encountered an unexpected property of rRNA secondary structures that may generalize to all RNAs. Analysis of 8892 ribosomal RNA sequences and structures from a wide range of species revealed unexpected universal compositional trends. First, different categories of rRNA secondary structure (stems, loops, bulges, and junctions) have distinct, characteristic base compositions. Second, the observed patterns of variation are similar among sequences from large and small rRNA subunits and all domains of life, despite extensive evolutionary divergence. Surprisingly, these differences do not seem to be related to selection for different compositions in different structural categories, but rather relate to the overall composition of the molecule: Randomized RNAs with no evolutionary history show the same structure-dependent compositional biases as rRNAs. These compositional trends may improve the accuracy of RNA secondary structure prediction, because they allow us to compare predicted structures against known compositional preferences. They also suggest caution in interpreting differences in the rate of change of the GC content in different parts of the molecule as evidence of differential selection.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-10329189, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-10368434, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-10368436, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-10673280, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11014182, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11070046, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11090278, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11125083, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11276255, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11296253, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11752288, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-11869452, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-12034839, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-12127448, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-1304880, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-13239693, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-13918160, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-13918161, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-15317972, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-15459373, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-15556293, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-15860776, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-2236056, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-2449689, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-3357886, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-3467347, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-6163133, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-7544890, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-875032, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-8781229, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-8939599, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-9169555, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-9214661, http://linkedlifedata.com/resource/pubmed/commentcorrection/16373489-9461405
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
1355-8382
pubmed:author
pubmed:issnType
Print
pubmed:volume
12
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-14
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Natural selection is not required to explain universal compositional patterns in rRNA secondary structure categories.
pubmed:affiliation
Department of Chemistry and Biochemistry, Campus Box 215, University of Colorado at Boulder, Boulder, CO 80309, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural