Linked Life Data

16373058

Source:http://linkedlifedata.com/resource/pubmed/id/16373058

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
2005-12-23
pubmed:abstractText
Double minutes are tiny spherical chromatin bodies of a few mega-base pairs of size which are found occasionally in hematopoietic neoplasia and more or less often in human solid tumors. They have been associated with worse prognosis and poor outcome of the malignancies where present. With the beginning era of molecular cytogenetics they could be defined as cytogenetic equivalents of amplified DNA sequences. The identification of involved chromosomal segments and their molecular nature led to the development of molecular genetic techniques for a rapid and reliable detection of prognostically important oncogene amplifications in human tumors and,as a consequence, to gene-targeted therapy.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1699-048X
pubmed:author
pubmed:issnType
Print
pubmed:volume
7
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
477-85
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Double minutes, cytogenetic equivalents of gene amplification, in human neoplasia - a review.
pubmed:affiliation
Institute of Human Genetics, University of Erlangen-Nürnberg, Germany. egebhart@humgenet.uni-erlangen.de
pubmed:publicationType
Journal Article, Review