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rdf:type |
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lifeskim:mentions |
|
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pubmed:issue |
7
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pubmed:dateCreated |
1992-8-27
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pubmed:abstractText |
In this study, we report the results of a prospective, double-blind trial to determine whether high-dose topical corticosteroids have an effect on refractive outcome or anterior stromal haze after photorefractive keratectomy. A total of 113 patients were allocated randomly to either placebo- or steroid-treated groups (0.1% dexamethasone metasulphobenzoate for 3 months) and underwent either -3.00-diopter (D) or -6.00-D procedures. At 6 weeks, the mean change in refraction was significantly greater in the steroid-treated group than in the placebo-treated group (-3.00-D group, P = .0015; -6.00-D group, P = .0011). However, when corticosteroids were discontinued at 3 months, this difference became statistically insignificant. There was no statistically significant effect on anterior stromal haze at any stage. Since long-term use of corticosteroids to maintain the initial beneficial effect on refraction would be unacceptable, we conclude that these agents should not be used after photorefractive keratectomy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
|
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0003-9950
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
110
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
944-52
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pubmed:dateRevised |
2007-11-15
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pubmed:meshHeading |
pubmed-meshheading:1637279-Administration, Topical,
pubmed-meshheading:1637279-Adrenal Cortex Hormones,
pubmed-meshheading:1637279-Adult,
pubmed-meshheading:1637279-Aged,
pubmed-meshheading:1637279-Chloramphenicol,
pubmed-meshheading:1637279-Corneal Opacity,
pubmed-meshheading:1637279-Cyclopentolate,
pubmed-meshheading:1637279-Double-Blind Method,
pubmed-meshheading:1637279-Female,
pubmed-meshheading:1637279-Humans,
pubmed-meshheading:1637279-Intraocular Pressure,
pubmed-meshheading:1637279-Laser Therapy,
pubmed-meshheading:1637279-Male,
pubmed-meshheading:1637279-Middle Aged,
pubmed-meshheading:1637279-Myopia,
pubmed-meshheading:1637279-Phenylephrine,
pubmed-meshheading:1637279-Postoperative Complications,
pubmed-meshheading:1637279-Prospective Studies,
pubmed-meshheading:1637279-Refraction, Ocular,
pubmed-meshheading:1637279-Time Factors,
pubmed-meshheading:1637279-Tropanes,
pubmed-meshheading:1637279-Wound Healing
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pubmed:year |
1992
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pubmed:articleTitle |
The effect of topical corticosteroids on refractive outcome and corneal haze after photorefractive keratectomy. A prospective, randomized, double-blind trial.
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pubmed:affiliation |
Department of Ophthalmology, St Thomas' Hospital, London, England.
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pubmed:publicationType |
Journal Article,
Clinical Trial,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
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