Source:http://linkedlifedata.com/resource/pubmed/id/16372136
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
2
|
| pubmed:dateCreated |
2006-1-25
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| pubmed:abstractText |
Bone mineral density (BMD), the major factor determining bone strength, is closely related to osteoporotic fracture risk and is determined largely by multiple genetic factors. Semaphorin 7a (SEMA7A), a recently described member of the semaphorin family, has been shown to play a critical role in the activation of monocyte/macrophages that share progenitors with bone-resorbing osteoclasts and thus might contribute to osteoclast development. In the present study, we directly sequenced the SEMA7A gene in 24 Korean individuals, and identified 15 sequence variants. Five polymorphisms (+15667G > A, +15775C > G, +16285C > T, +19317C > T, +22331A > G) were selected and genotyped in postmenopausal Korean women (n = 560) together with measurement of the areal BMD (g/cm2) of the anterior-posterior lumbar spine and the non-dominant proximal femur using dual-energy X-ray absorptiometry. We found that polymorphisms of the SEMA7A gene were associated with the BMD of the lumbar spine and femoral neck. SEMA7A + 15775C > G and SEMA7A+22331A > G were associated with low BMD of the femoral neck (P = 0.02) and lumbar spine (P = 0.04) in a recessive model. SEMA7A-ht4 also showed an association with risk of vertebral fracture (OR = 1.87-1.93, P = 0.02-0.03). Our results suggest that variations in SEMA7A may play a role in decreased BMD and risk of vertebral fracture.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
1434-5161
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| pubmed:author |
pubmed-author:CheongHyun SubHS,
pubmed-author:HongJung MinJM,
pubmed-author:KimGhi SuGS,
pubmed-author:KimShin-YoonSY,
pubmed-author:KimTae-HoTH,
pubmed-author:KimmKuchanK,
pubmed-author:KohJung-MinJM,
pubmed-author:LeeJong YongJY,
pubmed-author:LeeJong-KeukJK,
pubmed-author:OhBermseokB,
pubmed-author:ParkByung LaeBL,
pubmed-author:ParkEui KyunEK,
pubmed-author:ShinHyoung DooHD
|
| pubmed:issnType |
Print
|
| pubmed:volume |
51
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
112-7
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| pubmed:dateRevised |
2010-11-18
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| pubmed:meshHeading |
pubmed-meshheading:16372136-Absorptiometry, Photon,
pubmed-meshheading:16372136-Antigens, CD,
pubmed-meshheading:16372136-Base Sequence,
pubmed-meshheading:16372136-Bone Density,
pubmed-meshheading:16372136-Chromosome Mapping,
pubmed-meshheading:16372136-Chromosomes, Human, Pair 15,
pubmed-meshheading:16372136-Female,
pubmed-meshheading:16372136-Femur Head,
pubmed-meshheading:16372136-Fractures, Bone,
pubmed-meshheading:16372136-GPI-Linked Proteins,
pubmed-meshheading:16372136-Genetic Predisposition to Disease,
pubmed-meshheading:16372136-Haplotypes,
pubmed-meshheading:16372136-Humans,
pubmed-meshheading:16372136-Korea,
pubmed-meshheading:16372136-Lumbar Vertebrae,
pubmed-meshheading:16372136-Middle Aged,
pubmed-meshheading:16372136-Molecular Sequence Data,
pubmed-meshheading:16372136-Osteoporosis, Postmenopausal,
pubmed-meshheading:16372136-Polymorphism, Single Nucleotide,
pubmed-meshheading:16372136-Regression Analysis,
pubmed-meshheading:16372136-Semaphorins,
pubmed-meshheading:16372136-Sequence Analysis, DNA
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Association study of semaphorin 7a (sema7a) polymorphisms with bone mineral density and fracture risk in postmenopausal Korean women.
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| pubmed:affiliation |
Skeletal Diseases Genome Research Center, Kyungpook National University Hospital, 44-2, Samduk 2-ga, Jung-gu, 700-412 Daegu, Republic of Korea.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|