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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
7071
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pubmed:dateCreated |
2005-12-22
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pubmed:abstractText |
The aspergilli comprise a diverse group of filamentous fungi spanning over 200 million years of evolution. Here we report the genome sequence of the model organism Aspergillus nidulans, and a comparative study with Aspergillus fumigatus, a serious human pathogen, and Aspergillus oryzae, used in the production of sake, miso and soy sauce. Our analysis of genome structure provided a quantitative evaluation of forces driving long-term eukaryotic genome evolution. It also led to an experimentally validated model of mating-type locus evolution, suggesting the potential for sexual reproduction in A. fumigatus and A. oryzae. Our analysis of sequence conservation revealed over 5,000 non-coding regions actively conserved across all three species. Within these regions, we identified potential functional elements including a previously uncharacterized TPP riboswitch and motifs suggesting regulation in filamentous fungi by Puf family genes. We further obtained comparative and experimental evidence indicating widespread translational regulation by upstream open reading frames. These results enhance our understanding of these widely studied fungi as well as provide new insight into eukaryotic genome evolution and gene regulation.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1476-4687
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pubmed:author |
pubmed-author:ArcherDavid BDB,
pubmed-author:AsaiKiyoshiK,
pubmed-author:Ba?türkmenMerayM,
pubmed-author:BatzoglouSerafimS,
pubmed-author:Bell-PedersenDeborahD,
pubmed-author:BirrenBruce WBW,
pubmed-author:BouchierChristianeC,
pubmed-author:BrausGerhard HGH,
pubmed-author:BuschSilkeS,
pubmed-author:ButlerJonathanJ,
pubmed-author:CaddickMarkM,
pubmed-author:CalvoSarah ESE,
pubmed-author:ClutterbuckJohnJ,
pubmed-author:CuomoChristinaC,
pubmed-author:D'EnfertChristopheC,
pubmed-author:DenningDavid WDW,
pubmed-author:DoonanJohn HJH,
pubmed-author:DrahtOliverO,
pubmed-author:DyerPaulP,
pubmed-author:FarmanMarkM,
pubmed-author:FischerReinhardR,
pubmed-author:FreitagMichaelM,
pubmed-author:GalaganJames EJE,
pubmed-author:GoldmanGustavo HGH,
pubmed-author:Griffiths-JonesSamS,
pubmed-author:HarrisSteveS,
pubmed-author:HynesMichaelM,
pubmed-author:JurkaJerzyJ,
pubmed-author:KapitonovVladimirV,
pubmed-author:KumagaiToshitakaT,
pubmed-author:LeeSu-InSI,
pubmed-author:MaLi-JunLJ,
pubmed-author:MachidaMasayukiM,
pubmed-author:MillerBruceB,
pubmed-author:MomanyMichelleM,
pubmed-author:NiermanWilliam CWC,
pubmed-author:OakleyBerl RBR,
pubmed-author:OsmaniStephen ASA,
pubmed-author:PainArnabA,
pubmed-author:PaolettiMathieuM,
pubmed-author:PeñalvaMiguel AMA,
pubmed-author:PurcellSethS,
pubmed-author:SachsMatthew SMS,
pubmed-author:ScazzocchioClaudioC,
pubmed-author:SelkerEric UEU,
pubmed-author:SpevakChristina CCC,
pubmed-author:TanakaToshihiroT,
pubmed-author:VienkenKayK,
pubmed-author:WortmanJennifer RJR,
pubmed-author:YuJaehyukJ
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pubmed:issnType |
Electronic
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pubmed:day |
22
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pubmed:volume |
438
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1105-15
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16372000-Aspergillus fumigatus,
pubmed-meshheading:16372000-Aspergillus nidulans,
pubmed-meshheading:16372000-Aspergillus oryzae,
pubmed-meshheading:16372000-Base Sequence,
pubmed-meshheading:16372000-Consensus Sequence,
pubmed-meshheading:16372000-Conserved Sequence,
pubmed-meshheading:16372000-Evolution, Molecular,
pubmed-meshheading:16372000-Genes, Mating Type, Fungal,
pubmed-meshheading:16372000-Genome, Fungal,
pubmed-meshheading:16372000-Genomics,
pubmed-meshheading:16372000-Humans,
pubmed-meshheading:16372000-Molecular Sequence Data,
pubmed-meshheading:16372000-Open Reading Frames,
pubmed-meshheading:16372000-Phylogeny,
pubmed-meshheading:16372000-Proteome,
pubmed-meshheading:16372000-Regulatory Sequences, Nucleic Acid,
pubmed-meshheading:16372000-Sequence Analysis, DNA,
pubmed-meshheading:16372000-Synteny
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pubmed:year |
2005
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pubmed:articleTitle |
Sequencing of Aspergillus nidulans and comparative analysis with A. fumigatus and A. oryzae.
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pubmed:affiliation |
The Broad Institute of MIT and Harvard, 320 Charles Street, Cambridge, Massachusetts 02142, USA.
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pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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