Linked Life Data

16371459

Source:http://linkedlifedata.com/resource/pubmed/id/16371459

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-3-22
pubmed:abstractText
It is known that burst discharges in basal ganglia neurons are more common in parkinsonism than under normal conditions, but changes in the structure of burst or peri-burst epochs have not been reported. In this study, the temporal structure of bursts and the timing of neuronal discharges that precede or follow them were examined in neuronal spike trains recorded in the subthalamic nucleus (STN) and the external and internal pallidal segment (GPe, GPi) in two awake Rhesus monkeys before and after they were rendered hemiparkinsonian by unilateral intracarotid infusion of the dopaminergic neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP). Bursts were detected by the "surprise" method. In the normal state, interspike intervals (ISIs) preceding or following bursts were frequently significantly longer than the average baseline ISI, and their duration was correlated with the burst length (i.e., the number of spikes/burst). Significant correlations were also found in all three structures between the burst length and the duration of interburst intervals. The incidence of burst discharges and the proportion of time spent in bursts increased in GPe, STN, and GPi after MPTP treatment. Burst lengths became more tightly related to preburst ISIs in the STN after MPTP treatment and to postburst ISI duration in all three structures. These results show that bursts in spontaneous GPe, STN, and GPi discharge are often preceded or followed by long ISIs, and that burst length, the length of pre- and postburst ISIs, and the length of interburst intervals are related to one another. Complex changes in these interactions may contribute to abnormal information processing in parkinsonism.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0022-3077
pubmed:author
pubmed:issnType
Print
pubmed:volume
95
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
2120-33
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Neuronal firing before and after burst discharges in the monkey basal ganglia is predictably patterned in the normal state and altered in parkinsonism.
pubmed:affiliation
Department of Neurology, Emory University, Atlanta, GA 30322, USA. twichma@emory.edu
pubmed:publicationType
Journal Article, Comparative Study, Research Support, N.I.H., Extramural