Source:http://linkedlifedata.com/resource/pubmed/id/16371085
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-12-22
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| pubmed:abstractText |
Salvia divinorum is a widespread hallucinogenic herb traditionally employed for divination, as well as a medicament for several disorders including disturbances of gastrointestinal motility. In the present study we evaluated the effect of a standardized extract from the leaves of S. divinorum (SDE) on enteric cholinergic transmission in the guinea-pig ileum. SDE reduced electrically evoked contractions without modifying the contractions elicited by exogenous acetylcholine, thus suggesting a prejunctional site of action. The inhibitory effect of SDE on twitch response was abolished by the opioid receptor antagonist naloxone and by the kappa-opioid antagonist nor-binaltorphimine, but not by naltrindole (a delta-opioid receptor antagonist), CTOP (a mu-opioid receptor antagonist), thioperamide (a H(3) receptor antagonist), yohimbine (an alpha(2)-receptor antagonist), methysergide (a 5-hydroxytryptamine receptor antagonist), N(G)-nitro-L-arginine methyl ester (an inhibitor of NO synthase) or apamin (a blocker of Ca(2+)-activated K(+) channels). Salvinorin A, the main active ingredient of S. divinorum, inhibited in a nor-binaltorphimine- and naloxone-sensitive manner electrically induced contractions. It is concluded that SDE depressed enteric cholinergic transmission likely through activation of kappa-opioid receptors and this may provide the pharmacological basis underlying its traditional antidiarrhoeal use. Salvinorin A might be the chemical ingredient responsible for this activity.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Acetylcholine,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes,
http://linkedlifedata.com/resource/pubmed/chemical/Diterpenes, Clerodane,
http://linkedlifedata.com/resource/pubmed/chemical/Hallucinogens,
http://linkedlifedata.com/resource/pubmed/chemical/Plant Extracts,
http://linkedlifedata.com/resource/pubmed/chemical/salvinorin A
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| pubmed:status |
MEDLINE
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| pubmed:month |
Jan
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| pubmed:issn |
1350-1925
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
18
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
69-75
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16371085-Acetylcholine,
pubmed-meshheading:16371085-Animals,
pubmed-meshheading:16371085-Diterpenes,
pubmed-meshheading:16371085-Diterpenes, Clerodane,
pubmed-meshheading:16371085-Drug Interactions,
pubmed-meshheading:16371085-Electric Stimulation,
pubmed-meshheading:16371085-Enteric Nervous System,
pubmed-meshheading:16371085-Guinea Pigs,
pubmed-meshheading:16371085-Hallucinogens,
pubmed-meshheading:16371085-Ileum,
pubmed-meshheading:16371085-Male,
pubmed-meshheading:16371085-Muscle, Smooth, Vascular,
pubmed-meshheading:16371085-Muscle Contraction,
pubmed-meshheading:16371085-Myenteric Plexus,
pubmed-meshheading:16371085-Parasympathetic Nervous System,
pubmed-meshheading:16371085-Plant Extracts,
pubmed-meshheading:16371085-Salvia,
pubmed-meshheading:16371085-Stimulation, Chemical,
pubmed-meshheading:16371085-Synaptic Transmission
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| pubmed:year |
2006
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| pubmed:articleTitle |
The hallucinogenic herb Salvia divinorum and its active ingredient salvinorin A inhibit enteric cholinergic transmission in the guinea-pig ileum.
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| pubmed:affiliation |
Department of Experimental Pharmacology, University of Naples Federico II, Naples, Italy. rafcapas@unina.it
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| pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, Non-U.S. Gov't
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