Source:http://linkedlifedata.com/resource/pubmed/id/16371020
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
1
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| pubmed:dateCreated |
2005-12-22
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| pubmed:abstractText |
Cytotoxic T lymphocyte (CTL) lines specific for allogeneic antigens were generated by in vitro stimulation of donor-derived peripheral blood mononuclear cells obtained from patients who received human leucocyte antigen (HLA)-matched allogeneic haematopoietic stem cell transplantation (HSCT). One of the allogeneic antigen-specific CD4+ CTL lines, CTL-A, generated from a patient with T cell acute lymphoblastic leukaemia, recognised HLA-DPB1*0501-positive Epstein-Barr virus-immortalised human B cell line (EBV-B cells), phytohaemagglutinin blasts and leukaemia cells, but not interferon-gamma (IFN-gamma) treated HLA-DPB1*0501-positive fibroblasts, indicating that this CD4+ T-cell line recognised a minor histocompatibility antigen (mHa) that is preferentially expressed in haematopoietic cells in an HLA-DPB1*0501-restricted manner. The other CD4+ CTL line, CTL-B, generated from a patient with chronic myeloid leukaemia, recognised mismatched HLA-DQB1*0303 on EBV-B cells and phytohaemagglutinin (PHA) blasts. Interestingly, this CTL line did not recognise IFN-gamma-treated recipient's skin fibroblasts, as HLA-DQ was merely upregulated even after IFN-gamma stimulation in non-haematopoietic cells including fibroblasts, endothelial cells and hepatocytes. These results suggest that these CD4 positive CTLs, specific for mismatch HLA-DQ and mHa that are preferentially expressed on haematopoietic cells, may play an important role in induction of selective graft-versus-leukaemia effect without development of graft-versus-host disease after allogeneic HSCT.
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| pubmed:language |
eng
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| pubmed:journal | |
| pubmed:citationSubset |
IM
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| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jan
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| pubmed:issn |
0007-1048
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| pubmed:author | |
| pubmed:issnType |
Print
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| pubmed:volume |
132
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| pubmed:owner |
NLM
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| pubmed:authorsComplete |
Y
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| pubmed:pagination |
56-65
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| pubmed:dateRevised |
2008-11-21
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| pubmed:meshHeading |
pubmed-meshheading:16371020-CD4-Positive T-Lymphocytes,
pubmed-meshheading:16371020-Cell Line, Transformed,
pubmed-meshheading:16371020-Cell Transformation, Viral,
pubmed-meshheading:16371020-Epitopes, T-Lymphocyte,
pubmed-meshheading:16371020-Female,
pubmed-meshheading:16371020-Genes, MHC Class II,
pubmed-meshheading:16371020-Graft vs Host Disease,
pubmed-meshheading:16371020-Graft vs Leukemia Effect,
pubmed-meshheading:16371020-HLA-DP Antigens,
pubmed-meshheading:16371020-HLA-DQ Antigens,
pubmed-meshheading:16371020-Hematologic Neoplasms,
pubmed-meshheading:16371020-Hematopoietic Stem Cell Transplantation,
pubmed-meshheading:16371020-Herpesvirus 4, Human,
pubmed-meshheading:16371020-Histocompatibility Testing,
pubmed-meshheading:16371020-Humans,
pubmed-meshheading:16371020-Interferon-gamma,
pubmed-meshheading:16371020-Leukemia,
pubmed-meshheading:16371020-Male,
pubmed-meshheading:16371020-Tumor Cells, Cultured
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Possible involvement of allogeneic antigens recognised by donor-derived CD4 cytotoxic T cells in selective GVL effects after stem cell transplantation of patients with haematological malignancy.
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| pubmed:affiliation |
Division of Cellular Signaling, Institute for Advanced Medical Research, Keio University School of Medicine, Tokyo, Japan.
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| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|