Linked Life Data

16369943

Source:http://linkedlifedata.com/resource/pubmed/id/16369943

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-26
pubmed:abstractText
Wnt signalling through beta-catenin plays a pivotal role during embryonic pattern formation, cell fate determination and tissue homeostasis in the adult organism. In the skin, as in many other tissues, Wnt/beta-catenin signalling can control lineage determination and differentiation. However, it was not known whether Wnt/beta-catenin signalling is an immediate regulator of the stem cell niche in skin tissue. A recent publication now provides evidence that Wnt/beta-catenin signalling exerts a direct effect on the stem cell compartment by inducing quiescent stem cells to enter the cell cycle during early stages of hair follicle regeneration. In addition, the authors demonstrate that beta-catenin is required for maintenance of the stem cell pool in the tissue. The data suggest that a gradient in Wnt/beta-catenin activity levels can induce different responses within distinct cell populations reflected by activation of distinct transcriptional profiles.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0265-9247
pubmed:author
pubmed:copyrightInfo
2005 Wiley Periodicals, Inc.
pubmed:issnType
Print
pubmed:volume
28
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-5
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Controlling the stem cell niche: right time, right place, right strength.
pubmed:affiliation
Center for Molecular Medicine Cologne, University Cologne, Institute of Pathology, Joseph-Stelzmann-Strasse 9, D-50931 Cologne, Germany. cnieman1@uni-koeln.de
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't