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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
2006-1-20
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pubmed:abstractText |
Despite limited data supporting the superiority of dominant over subdominant responses, immunodominant epitopes represent the preferred vaccine candidates. To address the function of subdominant responses in human immunodeficiency virus infection, we analyzed cytotoxic T lymphocyte responses restricted by HLA-B*1503, a rare allele in a cohort infected with clade B, although common in one infected with clade C. HLA-B*1503 was associated with reduced viral loads in the clade B cohort but not the clade C cohort, although both shared the immunodominant response. Clade B viral control was associated with responses to several subdominant cytotoxic T lymphocyte epitopes, whereas their clade C variants were less well recognized. These data suggest that subdominant responses can contribute to in vivo viral control and that high HLA allele frequencies may drive the elimination of subdominant yet effective epitopes from circulating viral populations.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
1529-2908
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pubmed:author |
pubmed-author:AdamsSharonS,
pubmed-author:AddoMarylyn MMM,
pubmed-author:AllenTodd MTM,
pubmed-author:AltfeldMarcusM,
pubmed-author:BranderChristianC,
pubmed-author:CarringtonMaryM,
pubmed-author:FeeneyMargaret EME,
pubmed-author:FrahmNicoleN,
pubmed-author:GoulderPhilip J RPJ,
pubmed-author:HeckermanDavidD,
pubmed-author:HewittHannah SHS,
pubmed-author:KiepielaPhotiniP,
pubmed-author:KorberBette TBT,
pubmed-author:LahaieMatthew PMP,
pubmed-author:LichterfeldMathiasM,
pubmed-author:LindeCaitlyn HCH,
pubmed-author:MallalSimonS,
pubmed-author:MarincolaFrancesco MFM,
pubmed-author:MooreCoreyC,
pubmed-author:MullinsJames IJI,
pubmed-author:PaeEuniceE,
pubmed-author:RoachTimothyT,
pubmed-author:SangoKaoriK,
pubmed-author:St JohnM AnneMA,
pubmed-author:WalkerBruce DBD,
pubmed-author:WurcelAlysse GAG
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
173-8
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16369537-AIDS Vaccines,
pubmed-meshheading:16369537-Amino Acid Sequence,
pubmed-meshheading:16369537-Cohort Studies,
pubmed-meshheading:16369537-Epitope Mapping,
pubmed-meshheading:16369537-Epitopes,
pubmed-meshheading:16369537-Genetic Variation,
pubmed-meshheading:16369537-HIV Antigens,
pubmed-meshheading:16369537-HIV Infections,
pubmed-meshheading:16369537-HIV-1,
pubmed-meshheading:16369537-HLA-B Antigens,
pubmed-meshheading:16369537-HLA-B15 Antigen,
pubmed-meshheading:16369537-Humans,
pubmed-meshheading:16369537-Immunodominant Epitopes,
pubmed-meshheading:16369537-Molecular Sequence Data,
pubmed-meshheading:16369537-T-Lymphocytes, Cytotoxic,
pubmed-meshheading:16369537-Virus Replication
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pubmed:year |
2006
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pubmed:articleTitle |
Control of human immunodeficiency virus replication by cytotoxic T lymphocytes targeting subdominant epitopes.
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pubmed:affiliation |
Partners AIDS Research Center, Massachusetts General Hospital and Division of AIDS, Harvard Medical School, Boston, Massachusetts 02115, USA.
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pubmed:publicationType |
Journal Article,
In Vitro,
Research Support, U.S. Gov't, Non-P.H.S.,
Research Support, N.I.H., Extramural
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