Linked Life Data

16368995

Source:http://linkedlifedata.com/resource/pubmed/id/16368995

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-21
pubmed:abstractText
Correlates between immunological parameters and protection against Bacillus anthracis infection in animals vaccinated with protective antigen (PA)-based vaccines could provide surrogate markers to evaluate the putative protective efficiency of immunization in humans. In previous studies we demonstrated that neutralizing antibody levels serve as correlates for protection in guinea pigs (S. Reuveny et al., Infect. Immun. 69:2888-2893, 2001; H. Marcus et al., Infect. Immun. 72:3471-3477, 2004). In this study we evaluated similar correlates for protection by active and passive immunization of New Zealand White rabbits. Full immunization and partial immunization were achieved by single and multiple injections of standard and diluted doses of a PA-based vaccine. Passive immunization was carried out by injection of immune sera from rabbits vaccinated with PA-based vaccine prior to challenge with B. anthracis spores. Immunized rabbits were challenged by intranasal spore instillation with one of two virulent strains (strains Vollum and ATCC 6605). The immune competence was estimated by measuring the level of total anti-PA antibodies, the neutralizing antibody titers, and the conferred protective immunity. The results indicate that total anti-PA antibody titers greater than 1 x 10(5) conferred protection, whereas lower titers (between 10(4) and 10(5)) provided partial protection but failed to predict protection. Neutralizing antibody titers between 500 and 800 provided partial protection, while titers higher than 1,000 conferred protection. In conclusion, this study emphasizes that regardless of the immunization regimen or the time of challenge, neutralizing antibody titers are better predictors of protection than total anti-PA titers.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-11292703, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-11312020, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-11535328, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-11796581, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-12379702, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-14570563, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-14670324, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-15155654, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-15549606, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-15590776, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-15727841, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-3084385, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-3148815, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-9393812, http://linkedlifedata.com/resource/pubmed/commentcorrection/16368995-9822127
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0019-9567
pubmed:author
pubmed:issnType
Print
pubmed:volume
74
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
394-8
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Immunological correlates for protection against intranasal challenge of Bacillus anthracis spores conferred by a protective antigen-based vaccine in rabbits.
pubmed:affiliation
Department of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness-Ziona, Israel 74100.
pubmed:publicationType
Journal Article