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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-21
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pubmed:abstractText |
Thymic carcinoids are classified into three categories: (1) nonsecretory tumors, (2) hormonal secretory tumors, and (3) tumors associated with multiple endocrine neoplasia type 1. We report a rare case with adrenocorticotropic hormone secreting thymic carcinoid with multiple endocrine neoplasia type 1. Radiologic examination showed an anterior mediastinal mass and a parathyroid tumor. Blood analysis revealed high levels of parathyroid hormone and adrenocorticotropic hormone. Urine cortisol and 17-hydroxycorticoids levels were also elevated. Extended thymectomy was performed. Subsequently adjuvant radiation therapy and parathyroid tumor resection were performed. A germline mutation of exon 7 in the multiple endocrine neoplasia type 1 gene was detected and a somatic mutation of exon 9 was demonstrated in the thymic tumor.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1552-6259
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:volume |
81
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
366-8
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pubmed:meshHeading |
pubmed-meshheading:16368411-ACTH Syndrome, Ectopic,
pubmed-meshheading:16368411-Antineoplastic Agents, Hormonal,
pubmed-meshheading:16368411-Carcinoid Tumor,
pubmed-meshheading:16368411-Combined Modality Therapy,
pubmed-meshheading:16368411-DNA, Neoplasm,
pubmed-meshheading:16368411-DNA Mutational Analysis,
pubmed-meshheading:16368411-Exons,
pubmed-meshheading:16368411-Flushing,
pubmed-meshheading:16368411-Genes, Tumor Suppressor,
pubmed-meshheading:16368411-Humans,
pubmed-meshheading:16368411-Hypercalcemia,
pubmed-meshheading:16368411-Male,
pubmed-meshheading:16368411-Middle Aged,
pubmed-meshheading:16368411-Multiple Endocrine Neoplasia Type 1,
pubmed-meshheading:16368411-Octreotide,
pubmed-meshheading:16368411-Parathyroid Hormone,
pubmed-meshheading:16368411-Parathyroid Neoplasms,
pubmed-meshheading:16368411-Parathyroidectomy,
pubmed-meshheading:16368411-Pleural Neoplasms,
pubmed-meshheading:16368411-Radiotherapy, Adjuvant,
pubmed-meshheading:16368411-Thymectomy,
pubmed-meshheading:16368411-Thymus Neoplasms
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pubmed:year |
2006
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pubmed:articleTitle |
ACTH-secreting thymic carcinoid associated with multiple endocrine neoplasia type 1.
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pubmed:affiliation |
Department of Surgery II, Nagoya City University Medical School, Nagoya, Aichi, Japan. motoki@med.nagoya-cu.ac.jp
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pubmed:publicationType |
Journal Article,
Case Reports
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