Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:dateCreated
2005-12-21
pubmed:abstractText
Psychological/physical stresses have been reported to exacerbate auto-immune and inflammatory diseases. To clarify a mechanism by which non-inflammatory stresses disrupt host defenses, responses to immobilization stress in mice were investigated, focusing on the role of a multifunctional cytokine, interleukin-18 (IL-18). In the adrenal cortex, the stress induced IL-18 precursor proteins (pro-IL-18) via ACTH and a superoxide-mediated caspase-1 activation pathway, resulting in conversion of pro-IL-18 to the mature form which was released into plasma. Inhibitors of caspase-1, reactive oxygen species and P38 MAPK prevented stress-induced accumulation of plasma IL-18. These inhibitors also blocked stress-induced IL-6 expression. This, together with the observation that IL-6 was not induced in stressed-IL-18 deficient mice, showed that IL-6 induction by stress is dependent on IL-18. In stressed organisms, IL-18 may influence pathological and physiological processes. Controlling the caspase-1 activating pathway to suppress IL-18 levels may provide preventative means against stress-related disruption of host defenses.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1343-1420
pubmed:author
pubmed:issnType
Print
pubmed:volume
52 Suppl
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
236-9
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16366505-Adrenal Cortex, pubmed-meshheading:16366505-Adrenocorticotropic Hormone, pubmed-meshheading:16366505-Animals, pubmed-meshheading:16366505-Caspase 1, pubmed-meshheading:16366505-Enzyme Activation, pubmed-meshheading:16366505-Enzyme Inhibitors, pubmed-meshheading:16366505-Humans, pubmed-meshheading:16366505-Hypothalamo-Hypophyseal System, pubmed-meshheading:16366505-Immunoblotting, pubmed-meshheading:16366505-Immunohistochemistry, pubmed-meshheading:16366505-Interleukin-18, pubmed-meshheading:16366505-Interleukin-6, pubmed-meshheading:16366505-Medicine, pubmed-meshheading:16366505-Mice, pubmed-meshheading:16366505-Pituitary-Adrenal System, pubmed-meshheading:16366505-Reactive Oxygen Species, pubmed-meshheading:16366505-Restraint, Physical, pubmed-meshheading:16366505-Science, pubmed-meshheading:16366505-Stress, Psychological, pubmed-meshheading:16366505-Superoxides, pubmed-meshheading:16366505-Time Factors, pubmed-meshheading:16366505-Up-Regulation, pubmed-meshheading:16366505-p38 Mitogen-Activated Protein Kinases
pubmed:year
2005
pubmed:articleTitle
IL-18; a cytokine translates a stress into medical science.
pubmed:affiliation
Department of stress science, Institute of Health Biosciences, The University of Tokushima Graduate School, Japan.
pubmed:publicationType
Journal Article