|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:issue |
4
|
|
pubmed:dateCreated |
2006-1-24
|
|
pubmed:abstractText |
We investigated whether the mutant methylenetetrahydrofolate reductase (MTHFR) increases risk for oral cancer. The common germ-line mutation C677T in the MTHFR gene significantly diminishes specific activity of the enzyme, which is responsible for the circulating form of folate. Folate deficiency is associated with increased risk for thrombosis, as well as for several types of cancer, through disruption of DNA methylation, DNA synthesis and deficient DNA repair.
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Apr
|
|
pubmed:issn |
0171-5216
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:volume |
132
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
219-22
|
|
pubmed:meshHeading |
pubmed-meshheading:16365753-Adult,
pubmed-meshheading:16365753-Aged,
pubmed-meshheading:16365753-Aged, 80 and over,
pubmed-meshheading:16365753-Carcinoma, Squamous Cell,
pubmed-meshheading:16365753-Case-Control Studies,
pubmed-meshheading:16365753-Diet,
pubmed-meshheading:16365753-Female,
pubmed-meshheading:16365753-Gene Frequency,
pubmed-meshheading:16365753-Genetic Predisposition to Disease,
pubmed-meshheading:16365753-Humans,
pubmed-meshheading:16365753-Male,
pubmed-meshheading:16365753-Methylenetetrahydrofolate Reductase (NADPH2),
pubmed-meshheading:16365753-Middle Aged,
pubmed-meshheading:16365753-Mouth Neoplasms,
pubmed-meshheading:16365753-Polymorphism, Genetic,
pubmed-meshheading:16365753-Risk Factors
|
|
pubmed:year |
2006
|
|
pubmed:articleTitle |
Methylenetetrahydrofolate reductase polymorphism and minor increase of risk for oral cancer.
|
|
pubmed:affiliation |
Department of Maxillofacial Surgery, University of Athens Medical School, Athens, Greece.
|
|
pubmed:publicationType |
Journal Article,
Comparative Study,
Research Support, Non-U.S. Gov't
|
