| pubmed-article:16365447 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0449475 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0039215 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0205103 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0167627 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C2754997 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0003261 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C1552861 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C0724668 | lld:lifeskim |
| pubmed-article:16365447 | lifeskim:mentions | umls-concept:C1178694 | lld:lifeskim |
| pubmed-article:16365447 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16365447 | pubmed:dateCreated | 2005-12-20 | lld:pubmed |
| pubmed-article:16365447 | pubmed:abstractText | Streptococcus pneumoniae causes serious infections in children, the elderly, and immunocompromised patients. Protection against infections with S. pneumoniae is mediated through Abs against the capsular polysaccharides (caps-PS). We previously showed that the murine Ab response to caps-PS is dependent on CD40-CD40L interaction. In the present paper, we addressed the question of whether the CD40-CD40L-mediated modulation of the anti-caps-PS immune reaction is the result of a direct interaction between B lymphocytes and T lymphocytes or of an indirect interaction. SCID/SCID mice reconstituted with B lymphocytes from wild-type mice did not mount anti-caps-PS Abs. SCID/SCID mice reconstituted with B lymphocytes from wild-type mice and CD4+ T lymphocytes from wild-type mice but not CD4+ T lymphocytes from CD40L knockout mice stimulated the anti-caps-PS Ab response. This indicated that CD4+ T lymphocytes stimulated the anti-caps-PS Ab response in a CD40L-dependent manner. SCID/SCID mice reconstituted with B lymphocytes from CD40 knockout mice and CD4+ T lymphocytes from wild-type mice generated an anti-caps-PS Ab response that could be inhibited by MR1, a blocking anti-CD40L Ab. These data indicated that CD4+ T lymphocytes stimulated the anti-caps-PS Ab response in an indirect way. Finally, lethally irradiated CD40 knockout mice reconstituted with bone marrow from wild-type mice mounted an anti-caps-PS Ab response that was comparable to the Ab response in wild-type mice, revealing that the required CD40 was on hemopoietic cells. In conclusion, we provide evidence that CD4+ T lymphocytes expressing CD40L stimulate the Ab response to soluble caps-PS by interacting with CD40-expressing non-B cells. | lld:pubmed |
| pubmed-article:16365447 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16365447 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365447 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16365447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365447 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365447 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16365447 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16365447 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:BossuytXavier... | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:CeuppensJan... | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:LanduytWillyW | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:JeurissenAxel... | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:BoonLouisL | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:WaerMarkM | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:BilliauAn DAD | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:LiShengqiaoS | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:LOPESD MDM | lld:pubmed |
| pubmed-article:16365447 | pubmed:author | pubmed-author:WuytsGreetG | lld:pubmed |
| pubmed-article:16365447 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16365447 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16365447 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16365447 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16365447 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16365447 | pubmed:pagination | 529-36 | lld:pubmed |
| pubmed-article:16365447 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
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| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:meshHeading | pubmed-meshheading:16365447... | lld:pubmed |
| pubmed-article:16365447 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16365447 | pubmed:articleTitle | CD4+ T lymphocytes expressing CD40 ligand help the IgM antibody response to soluble pneumococcal polysaccharides via an intermediate cell type. | lld:pubmed |
| pubmed-article:16365447 | pubmed:affiliation | Laboratory of Experimental Laboratory Medicine, Department of Medical Diagnostic Sciences, Catholic University, Leuven Belgium. | lld:pubmed |
| pubmed-article:16365447 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16365447 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:21939 | entrezgene:pubmed | pubmed-article:16365447 | lld:entrezgene |
| entrez-gene:21947 | entrezgene:pubmed | pubmed-article:16365447 | lld:entrezgene |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:16365447 | lld:pubmed |
