| pubmed-article:16365394 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0014609 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0599757 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0596638 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C1171362 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C1414962 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C1424460 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C1515670 | lld:lifeskim |
| pubmed-article:16365394 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:16365394 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16365394 | pubmed:dateCreated | 2005-12-20 | lld:pubmed |
| pubmed-article:16365394 | pubmed:abstractText | The recently identified CXCL16 has dual functions as a transmembrane adhesion molecule and a soluble chemokine. In this study we found that CXCL16 mRNA and protein were expressed constitutively on the follicle-associated epithelium covering Peyer's patches (PPs), isolated lymphoid follicles, and cecal patches, but minimally on the villous epithelium in the murine gastrointestinal tract. The CXCL16 receptor CXCR6/Bonzo was constitutively expressed on subpopulations of CD4+ and CD8+ T cells isolated from PPs. The expression of CXCR6/Bonzo on the PP T cells was up-regulated after stimulation with anti-CD3 and anti-CD28 mAbs. The activated PP T cells showed chemotactic migration in response to the soluble N-terminal chemokine domain of CXCL16. Furthermore, the activated PP T cells selectively adhered to cells expressing murine CXCL16. To determine the physiological role of CXCL16 in GALT, we first carefully analyzed T cell distribution in PPs. T cells localized not only in the interfollicular region but also at a lesser frequency in the subepithelial dome (SED) and in the germinal center of lymphoid follicles. Consistently, the majority of the adoptive transferred activated T cells migrated into the SED and the interfollicular region. However, the neutralization of CXCL16 specifically reduced the migration of the adoptive, transferred, activated T cells into the SED of PPs. These data suggest that CXCL16 expressed on the follicle-associated epithelium plays an important role in the recruitment and retention of activated T cells in the SED and should, at least partially, be responsible for lymphocyte compartmentalization in GALT. | lld:pubmed |
| pubmed-article:16365394 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16365394 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365394 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:16365394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16365394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16365394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365394 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16365394 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16365394 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16365394 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:TakatsuHiroyu... | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:OhnoHiroshiH | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:HaseKojiK | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:YoneharaShinS | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:ShimaokaTakes... | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:ItohKikujiK | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:KawanoKazuyaK | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:IimuraMitsuto... | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:MurakamiTakay... | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:OhshimaSayaka... | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:HamuraKimiyoK | lld:pubmed |
| pubmed-article:16365394 | pubmed:author | pubmed-author:ChiharaRisaR | lld:pubmed |
| pubmed-article:16365394 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16365394 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:16365394 | pubmed:volume | 176 | lld:pubmed |
| pubmed-article:16365394 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16365394 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16365394 | pubmed:pagination | 43-51 | lld:pubmed |
| pubmed-article:16365394 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:16365394 | pubmed:meshHeading | pubmed-meshheading:16365394... | lld:pubmed |
| pubmed-article:16365394 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16365394 | pubmed:articleTitle | The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT. | lld:pubmed |
| pubmed-article:16365394 | pubmed:affiliation | Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa, Japan. | lld:pubmed |
| pubmed-article:16365394 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16365394 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:66102 | entrezgene:pubmed | pubmed-article:16365394 | lld:entrezgene |
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