Linked Life Data

16365394

Source:http://linkedlifedata.com/resource/pubmed/id/16365394

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-20
pubmed:abstractText
The recently identified CXCL16 has dual functions as a transmembrane adhesion molecule and a soluble chemokine. In this study we found that CXCL16 mRNA and protein were expressed constitutively on the follicle-associated epithelium covering Peyer's patches (PPs), isolated lymphoid follicles, and cecal patches, but minimally on the villous epithelium in the murine gastrointestinal tract. The CXCL16 receptor CXCR6/Bonzo was constitutively expressed on subpopulations of CD4+ and CD8+ T cells isolated from PPs. The expression of CXCR6/Bonzo on the PP T cells was up-regulated after stimulation with anti-CD3 and anti-CD28 mAbs. The activated PP T cells showed chemotactic migration in response to the soluble N-terminal chemokine domain of CXCL16. Furthermore, the activated PP T cells selectively adhered to cells expressing murine CXCL16. To determine the physiological role of CXCL16 in GALT, we first carefully analyzed T cell distribution in PPs. T cells localized not only in the interfollicular region but also at a lesser frequency in the subepithelial dome (SED) and in the germinal center of lymphoid follicles. Consistently, the majority of the adoptive transferred activated T cells migrated into the SED and the interfollicular region. However, the neutralization of CXCL16 specifically reduced the migration of the adoptive, transferred, activated T cells into the SED of PPs. These data suggest that CXCL16 expressed on the follicle-associated epithelium plays an important role in the recruitment and retention of activated T cells in the SED and should, at least partially, be responsible for lymphocyte compartmentalization in GALT.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0022-1767
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
176
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
43-51
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed-meshheading:16365394-Adoptive Transfer, pubmed-meshheading:16365394-Animals, pubmed-meshheading:16365394-Antigens, CD4, pubmed-meshheading:16365394-Antigens, CD8, pubmed-meshheading:16365394-Chemokine CXCL6, pubmed-meshheading:16365394-Chemokines, pubmed-meshheading:16365394-Chemokines, CXC, pubmed-meshheading:16365394-Chemotaxis, Leukocyte, pubmed-meshheading:16365394-Flow Cytometry, pubmed-meshheading:16365394-Gastric Mucosa, pubmed-meshheading:16365394-Gene Expression, pubmed-meshheading:16365394-Gene Expression Profiling, pubmed-meshheading:16365394-Immunohistochemistry, pubmed-meshheading:16365394-In Situ Hybridization, pubmed-meshheading:16365394-Intestinal Mucosa, pubmed-meshheading:16365394-Mice, pubmed-meshheading:16365394-Peyer's Patches, pubmed-meshheading:16365394-Polymerase Chain Reaction, pubmed-meshheading:16365394-RNA, Messenger, pubmed-meshheading:16365394-Receptors, Scavenger, pubmed-meshheading:16365394-T-Lymphocytes
pubmed:year
2006
pubmed:articleTitle
The membrane-bound chemokine CXCL16 expressed on follicle-associated epithelium and M cells mediates lympho-epithelial interaction in GALT.
pubmed:affiliation
Research Center for Allergy and Immunology, RIKEN, Yokohama, Kanagawa, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't