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rdf:type |
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lifeskim:mentions |
umls-concept:C0004561,
umls-concept:C0017262,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0332307,
umls-concept:C0567416,
umls-concept:C0871261,
umls-concept:C0936012,
umls-concept:C1423842,
umls-concept:C1704632,
umls-concept:C1706817,
umls-concept:C2911684,
umls-concept:C2911692
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pubmed:issue |
15
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pubmed:dateCreated |
2006-3-20
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pubmed:abstractText |
Previous studies show that the generation of maximal T cell responses requires B cell antigen presentation and the differential expression of costimulatory molecules by B cells may affect polarization of naïve T cells to Th1 or Th2 phenotypes. We have therefore characterized the expression of activation and costimulatory molecules on antigen-specific T and B cells following immunisation with Alum or Alum/LPS to induce Th2 or Th1 responses in vivo. While antigen-specific B cells show similar levels of activation with respect to MHCII upregulation following Th1 or Th2 induction, they differentially express costimulatory molecules. Although ICOS-B7RP-1 interactions were originally implicated in Th2 generation, surprisingly this receptor-ligand pair was only upregulated on antigen-specific T and B cells following Th1 induction. In conclusion, these studies indicate that during the generation of antigen-specific Th1 or Th2 responses, adjuvants induce differential costimulation in antigen-specific B cells that may subsequently influence T cell polarization.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Alum Compounds,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, CD80,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Differentiation...,
http://linkedlifedata.com/resource/pubmed/chemical/Histocompatibility Antigens Class II,
http://linkedlifedata.com/resource/pubmed/chemical/Icos protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Inducible T-Cell Co-Stimulator...,
http://linkedlifedata.com/resource/pubmed/chemical/Lipopolysaccharides,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Ovalbumin,
http://linkedlifedata.com/resource/pubmed/chemical/Tnfsf4 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Necrosis Factors,
http://linkedlifedata.com/resource/pubmed/chemical/aluminum sulfate
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pubmed:status |
MEDLINE
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pubmed:month |
Apr
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
5
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
3035-43
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16364514-Adjuvants, Immunologic,
pubmed-meshheading:16364514-Alum Compounds,
pubmed-meshheading:16364514-Animals,
pubmed-meshheading:16364514-Antigens, CD80,
pubmed-meshheading:16364514-Antigens, Differentiation, B-Lymphocyte,
pubmed-meshheading:16364514-Antigens, Differentiation, T-Lymphocyte,
pubmed-meshheading:16364514-B-Lymphocytes,
pubmed-meshheading:16364514-Histocompatibility Antigens Class II,
pubmed-meshheading:16364514-Inducible T-Cell Co-Stimulator Ligand,
pubmed-meshheading:16364514-Inducible T-Cell Co-Stimulator Protein,
pubmed-meshheading:16364514-Lipopolysaccharides,
pubmed-meshheading:16364514-Lymphocyte Activation,
pubmed-meshheading:16364514-Membrane Glycoproteins,
pubmed-meshheading:16364514-Mice,
pubmed-meshheading:16364514-Ovalbumin,
pubmed-meshheading:16364514-T-Lymphocytes,
pubmed-meshheading:16364514-Th1 Cells,
pubmed-meshheading:16364514-Th2 Cells,
pubmed-meshheading:16364514-Tumor Necrosis Factors,
pubmed-meshheading:16364514-Up-Regulation
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pubmed:year |
2006
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pubmed:articleTitle |
Analysis of costimulatory molecule expression on antigen-specific T and B cells during the induction of adjuvant-induced Th1 and Th2 type responses.
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pubmed:affiliation |
Division of Immunology, Infection & Inflammation, University of Glasgow, Glasgow, G11 6NT, UK. kms12a@clinmed.gla.ac.uk
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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