| pubmed-article:16364318 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C1140680 | lld:lifeskim |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C0699919 | lld:lifeskim |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C0162638 | lld:lifeskim |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C0033684 | lld:lifeskim |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:16364318 | lifeskim:mentions | umls-concept:C1826407 | lld:lifeskim |
| pubmed-article:16364318 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:16364318 | pubmed:dateCreated | 2006-1-2 | lld:pubmed |
| pubmed-article:16364318 | pubmed:abstractText | Increasing evidence suggests that lysosomal cysteine proteases cathepsins contribute to the progression of cell apoptosis. Here we found that apoptosis of ovarian cancer cells OV-90 triggered by TNF was cathepsin B-depended. Two cathepsin B binding proteins, bikunin and TSRC1, were identified by yeast two-hybrid method and the interactions were confirmed in vitro and in vivo. Overexpression of bikunin could suppress TNF-induced apoptosis of OV-90 cells, and TSRC1 overexpression had an opposite effect on apoptosis. The presented results suggest that cathepsin B and its interacting proteins, bikunin and TSRC1, are involved in the apoptotic pathway of ovarian cancer cells. | lld:pubmed |
| pubmed-article:16364318 | pubmed:language | eng | lld:pubmed |
| pubmed-article:16364318 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:16364318 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:16364318 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:16364318 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:16364318 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:LuHongH | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:LiuJianpingJ | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:QianGuoG | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:YaoYuY | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:LiYu-YangYY | lld:pubmed |
| pubmed-article:16364318 | pubmed:author | pubmed-author:ChenBuxinB | lld:pubmed |
| pubmed-article:16364318 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:16364318 | pubmed:day | 9 | lld:pubmed |
| pubmed-article:16364318 | pubmed:volume | 580 | lld:pubmed |
| pubmed-article:16364318 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:16364318 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:16364318 | pubmed:pagination | 245-50 | lld:pubmed |
| pubmed-article:16364318 | pubmed:dateRevised | 2007-5-23 | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
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| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
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| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:meshHeading | pubmed-meshheading:16364318... | lld:pubmed |
| pubmed-article:16364318 | pubmed:year | 2006 | lld:pubmed |
| pubmed-article:16364318 | pubmed:articleTitle | Cathepsin B and its interacting proteins, bikunin and TSRC1, correlate with TNF-induced apoptosis of ovarian cancer cells OV-90. | lld:pubmed |
| pubmed-article:16364318 | pubmed:affiliation | State Key Laboratory of Genetic Engineering, Institute of Genetics, School of Life Sciences, Fudan University, 220 Handan Road, Shanghai 200433, PR China. | lld:pubmed |
| pubmed-article:16364318 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:16364318 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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