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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-26
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pubmed:abstractText |
AMP-activated protein kinase (AMPK) activation increases fatty acid oxidation in skeletal muscle by decreasing malonyl CoA concentrations. However, this may not explain the long-term effects of AMPK activation. Here we show that AMPK activation by 5-aminoimidazole-4-carboxamide ribonucleoside (AICAR) increases mRNA expression of PPARalpha target genes and PGC-1 in cultured muscle cells and mouse skeletal muscle, and that inhibition of PPARalpha and PGC-1 by siRNAs prevents AICAR-stimulated increase in fatty acid oxidation. These data suggest that a novel transcriptional regulatory mechanism involving PPARalpha and PGC-1 exists that is responsible for long-term stimulation of fatty acid oxidation in skeletal muscle by AICAR.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0006-291X
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pubmed:author |
pubmed-author:JeonMin JaeMJ,
pubmed-author:KimHyoun SikHS,
pubmed-author:KimMin-SeonMS,
pubmed-author:KohEun HeeEH,
pubmed-author:LeeKi-UpKU,
pubmed-author:LeeWoo JeWJ,
pubmed-author:MeloR IRI,
pubmed-author:OhGoo TaegGT,
pubmed-author:OhKi SookKS,
pubmed-author:ParkHye-SunHS,
pubmed-author:ParkJoong-YeolJY,
pubmed-author:WonJong ChulJC,
pubmed-author:YoonMichungM
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pubmed:issnType |
Print
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pubmed:day |
3
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pubmed:volume |
340
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
291-5
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16364253-AMP-Activated Protein Kinases,
pubmed-meshheading:16364253-Aminoimidazole Carboxamide,
pubmed-meshheading:16364253-Animals,
pubmed-meshheading:16364253-Cells, Cultured,
pubmed-meshheading:16364253-Enzyme Activation,
pubmed-meshheading:16364253-Fatty Acids,
pubmed-meshheading:16364253-Lipid Peroxidation,
pubmed-meshheading:16364253-Mice,
pubmed-meshheading:16364253-Mice, Inbred C57BL,
pubmed-meshheading:16364253-Mice, Knockout,
pubmed-meshheading:16364253-Multienzyme Complexes,
pubmed-meshheading:16364253-Muscle, Skeletal,
pubmed-meshheading:16364253-Myoblasts, Skeletal,
pubmed-meshheading:16364253-Oxidation-Reduction,
pubmed-meshheading:16364253-PPAR alpha,
pubmed-meshheading:16364253-Protein-Serine-Threonine Kinases,
pubmed-meshheading:16364253-Ribonucleotides,
pubmed-meshheading:16364253-Transcription Factors,
pubmed-meshheading:16364253-Transcriptional Activation
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pubmed:year |
2006
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pubmed:articleTitle |
AMPK activation increases fatty acid oxidation in skeletal muscle by activating PPARalpha and PGC-1.
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pubmed:affiliation |
Department of Internal Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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