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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
2005-12-20
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pubmed:abstractText |
The C-type lectin DC-SIGNR has been shown to bind hepatitis C virus (HCV). Here, we analysed the tandem-repeat polymorphism of the DC-SIGNR gene with respect to intraindividual HCV replication. In a cross-sectional comparison HCV-infected patients (n = 430) and healthy subjects (n = 100) were genotyped for the DC-SIGNR polymorphism using PCR. The distribution of DC-SIGNR alleles did not differ significantly between the two groups. However, HCV-infected patients with 5-, 6-, and 7-repeat alleles had higher HCV-RNA levels when compared with carriers of 4- and 9-repeat alleles (P < 0.05). Thus, the DC-SIGNR polymorphism might affect HCV loads supporting the concept that DC-SIGNR contributes to HCV replication efficacy.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
1352-0504
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
13
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
42-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16364081-Adult,
pubmed-meshheading:16364081-Aged,
pubmed-meshheading:16364081-Alleles,
pubmed-meshheading:16364081-Cell Adhesion Molecules,
pubmed-meshheading:16364081-Cross-Sectional Studies,
pubmed-meshheading:16364081-DNA,
pubmed-meshheading:16364081-Female,
pubmed-meshheading:16364081-Genotype,
pubmed-meshheading:16364081-Hepacivirus,
pubmed-meshheading:16364081-Hepatitis C,
pubmed-meshheading:16364081-Humans,
pubmed-meshheading:16364081-Lectins, C-Type,
pubmed-meshheading:16364081-Logistic Models,
pubmed-meshheading:16364081-Male,
pubmed-meshheading:16364081-Microsatellite Repeats,
pubmed-meshheading:16364081-Middle Aged,
pubmed-meshheading:16364081-Polymerase Chain Reaction,
pubmed-meshheading:16364081-Polymorphism, Genetic,
pubmed-meshheading:16364081-Receptors, Cell Surface,
pubmed-meshheading:16364081-Tandem Repeat Sequences
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pubmed:year |
2006
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pubmed:articleTitle |
The tandem-repeat polymorphism of the DC-SIGNR gene in HCV infection.
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pubmed:affiliation |
Department of Internal Medicine I, Rheinische Friedrich Wilhelms Universität Bonn, Bonn, Germany. jacob.nattermann@ukb.uni-bonn.de
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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