Linked Life Data

16362926

Source:http://linkedlifedata.com/resource/pubmed/id/16362926

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
2005-12-19
pubmed:abstractText
A major challenge in cancer diagnosis from microarray data is the need for robust, accurate, classification models which are independent of the analysis techniques used and can combine data from different laboratories. We propose such a classification scheme originally developed for phenotype identification from mass spectrometry data. The method uses a robust multivariate gene selection procedure and combines the results of several machine learning tools trained on raw and pattern data to produce an accurate meta-classifier. We illustrate and validate our method by applying it to gene expression datasets: the oligonucleotide HuGeneFL microarray dataset of Shipp et al. (www.genome.wi.mit.du/MPR/lymphoma) and the Hu95Av2 Affymetrix dataset (DallaFavera's laboratory, Columbia University). Our pattern-based meta-classification technique achieves higher predictive accuracies than each of the individual classifiers , is robust against data perturbations and provides subsets of related predictive genes. Our techniques predict that combinations of some genes in the p53 pathway are highly predictive of phenotype. In particular, we find that in 80% of DLBCL cases the mRNA level of at least one of the three genes p53, PLK1 and CDK2 is elevated, while in 80% of FL cases, the mRNA level of at most one of them is elevated.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0919-9454
pubmed:author
pubmed:issnType
Print
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
233-44
pubmed:dateRevised
2011-11-2
pubmed:meshHeading
pubmed-meshheading:16362926-Cell Cycle Proteins, pubmed-meshheading:16362926-Clinical Laboratory Techniques, pubmed-meshheading:16362926-Computational Biology, pubmed-meshheading:16362926-Computer Simulation, pubmed-meshheading:16362926-Cyclin-Dependent Kinase 2, pubmed-meshheading:16362926-Databases, Factual, pubmed-meshheading:16362926-Diagnosis, Differential, pubmed-meshheading:16362926-Gene Expression Regulation, Neoplastic, pubmed-meshheading:16362926-Genes, Neoplasm, pubmed-meshheading:16362926-Genes, p53, pubmed-meshheading:16362926-Humans, pubmed-meshheading:16362926-Laboratories, pubmed-meshheading:16362926-Lymphoma, Follicular, pubmed-meshheading:16362926-Lymphoma, Large B-Cell, Diffuse, pubmed-meshheading:16362926-Lymphoma, Non-Hodgkin, pubmed-meshheading:16362926-Oligonucleotide Array Sequence Analysis, pubmed-meshheading:16362926-Phenotype, pubmed-meshheading:16362926-Predictive Value of Tests, pubmed-meshheading:16362926-Protein Kinases, pubmed-meshheading:16362926-Protein-Serine-Threonine Kinases, pubmed-meshheading:16362926-Proto-Oncogene Proteins, pubmed-meshheading:16362926-RNA, Messenger, pubmed-meshheading:16362926-Reproducibility of Results, pubmed-meshheading:16362926-Software Design, pubmed-meshheading:16362926-Tumor Markers, Biological, pubmed-meshheading:16362926-Tumor Suppressor Protein p53, pubmed-meshheading:16362926-Up-Regulation
pubmed:year
2005
pubmed:articleTitle
Robust diagnosis of non-Hodgkin lymphoma phenotypes validated on gene expression data from different laboratories.
pubmed:affiliation
Center for Systems Biology, Institute for Advanced Study, Princeton, NJ 08540, USA. gyan@us.ibm.com
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't