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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
24 Pt 1
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pubmed:dateCreated |
2005-12-19
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pubmed:abstractText |
Dihydropyrimidine dehydrogenase (DPD) deficiency, a known pharmacogenetic syndrome associated with 5-fluorouracil (5-FU) toxicity, has been detected in 3% to 5% of the population. Genotypic studies have identified >32 sequence variants in the DPYD gene; however, in a number of cases, sequence variants could not explain the molecular basis of DPD deficiency. Recent studies in cell lines indicate that hypermethylation of the DPYD promoter might down-regulate DPD expression. The current study investigates the role of methylation in cancer patients with an unexplained molecular basis of DPD deficiency.
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pubmed:grant |
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1078-0432
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
15
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pubmed:volume |
11
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
8699-705
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16361556-Adult,
pubmed-meshheading:16361556-Antimetabolites, Antineoplastic,
pubmed-meshheading:16361556-Chromatography, High Pressure Liquid,
pubmed-meshheading:16361556-CpG Islands,
pubmed-meshheading:16361556-DNA Methylation,
pubmed-meshheading:16361556-Dihydrouracil Dehydrogenase (NADP),
pubmed-meshheading:16361556-Down-Regulation,
pubmed-meshheading:16361556-Female,
pubmed-meshheading:16361556-Fluorouracil,
pubmed-meshheading:16361556-Genotype,
pubmed-meshheading:16361556-Humans,
pubmed-meshheading:16361556-Male,
pubmed-meshheading:16361556-Middle Aged,
pubmed-meshheading:16361556-Mutation,
pubmed-meshheading:16361556-Neoplasms,
pubmed-meshheading:16361556-Nucleic Acid Denaturation,
pubmed-meshheading:16361556-Phenotype,
pubmed-meshheading:16361556-Promoter Regions, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Methylation of the DPYD promoter: an alternative mechanism for dihydropyrimidine dehydrogenase deficiency in cancer patients.
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pubmed:affiliation |
Division of Clinical Pharmacology and Toxicology, Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama 35294-3300, USA.
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pubmed:publicationType |
Journal Article,
Research Support, N.I.H., Extramural
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