Linked Life Data

16359866

Source:http://linkedlifedata.com/resource/pubmed/id/16359866

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
2006-1-9
pubmed:abstractText
A series of partial structures of ketoconazole has been synthesized and tested for activity on the large conductance calcium-activated potassium channel (BK) in bovine smooth muscle cells. This has provided openers and blockers of the channel. The results suggest that the phenyl and phenoxy moieties are important for interaction with BK, whereas the imidazole group is unimportant. The properties of the phenoxy moiety seem to determine whether the compounds act to open or block the channel.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
887-90
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)).
pubmed:affiliation
Department of Chemistry, University College London, 20 Gordon Street, London WC1H 0AJ, UK. epower@sienabiotech.it
pubmed:publicationType
Journal Article