Source:http://linkedlifedata.com/resource/pubmed/id/16358261
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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
10
|
| pubmed:dateCreated |
2006-3-6
|
| pubmed:abstractText |
Interleukin 1beta (IL-1beta) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T-31C and C-511T) in the IL-1beta gene promoter were suggested to be correlated with alteration of IL-1beta expression and therefore may be associated with cancer risk. To test the hypothesis that these 2 polymorphisms are associated with risk of breast cancer, we performed a case-control study of 365 breast cancer cases, 270 patients with benign breast diseases (BBD) and 631 cancer-free controls in a Chinese population. Multivariate logistic regression analyses revealed that increased risk of breast cancer was associated with IL-1beta-31C variant genotypes [adjusted odds ratio (OR)=1.28 and 95% confidence interval (CI)=0.91-1.80 for -31CT and 1.72 (95% CI=1.16-2.54) for -31CC], compared with the -31TT genotype. Similarly, IL-1beta-511T variant genotypes were also associated with increased risk of breast cancer (adjusted OR=1.20, 95% CI=0.86-1.67 for -511CT and adjusted OR=1.74, 95% CI=1.18-2.56 for -511TT), compared with the -511CC genotype. Furthermore, cancer risks associated with IL-1betaT-31C variant genotypes were more evident in older women, postmenopausal women and individuals with a later menarche age. Interestingly, although we did not find significant associations of these 2 variants with cancer risk when compared with the BBD patients, a 1.27-fold (95% CI=1.01-1.60) increased risk was observed with the -31C-511T common haplotype. These findings indicate that these 2 IL-1beta promoter variants may contribute to risk of developing breast cancer in the Chinese population.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0020-7136
|
| pubmed:author |
pubmed-author:CoxS GSG,
pubmed-author:HuZhibinZ,
pubmed-author:JinGuangfuG,
pubmed-author:LiuJiyongJ,
pubmed-author:MaHongxiaH,
pubmed-author:QinJianweiJ,
pubmed-author:ShenHongbingH,
pubmed-author:WangShuiS,
pubmed-author:WangXinruX,
pubmed-author:WangXuechenX,
pubmed-author:WeiQingyiQ,
pubmed-author:ZhaiXiangjunX
|
| pubmed:copyrightInfo |
Copyright (c) 2005 Wiley-Liss, Inc.
|
| pubmed:issnType |
Print
|
| pubmed:day |
15
|
| pubmed:volume |
118
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
2554-8
|
| pubmed:dateRevised |
2008-11-21
|
| pubmed:meshHeading |
pubmed-meshheading:16358261-Adult,
pubmed-meshheading:16358261-Breast Neoplasms,
pubmed-meshheading:16358261-Case-Control Studies,
pubmed-meshheading:16358261-China,
pubmed-meshheading:16358261-Female,
pubmed-meshheading:16358261-Genotype,
pubmed-meshheading:16358261-Humans,
pubmed-meshheading:16358261-Interleukin-1,
pubmed-meshheading:16358261-Middle Aged,
pubmed-meshheading:16358261-Odds Ratio,
pubmed-meshheading:16358261-Polymorphism, Genetic,
pubmed-meshheading:16358261-Promoter Regions, Genetic,
pubmed-meshheading:16358261-Risk Factors
|
| pubmed:year |
2006
|
| pubmed:articleTitle |
Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.
|
| pubmed:affiliation |
Laboratory of Reproductive Medicine & Applied Toxicology, Nanjing Medical University, and Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, 210029, People's Republic of China.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|