Linked Life Data

16357781

Source:http://linkedlifedata.com/resource/pubmed/id/16357781

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
2005-12-16
pubmed:abstractText
Tolerance is one of the major requirements of a successful immune system: destroy invaders but recognize self and the benign environment to leave them alone. Central tolerance is achieved by deletion of T-cells with T-cell antigen receptors that recognize self-antigens too well. However, within the population of T-cells that actually survive the harrowing experience of passage through the thymus (wherein over 98% of all pre-T-cells perish), there persist T-cells capable of inducing autoimmune damage. How then to avoid autoaggression? One theory in the 1970s was that there were peripheral T-suppressor cells that actively dampened these autoimmune proclivities. One problem presented itself, however; despite the fact that such an immunologic activity could be measured, no one could identify the cells that mediated the activity and so the concept fell into disfavor. However, the concept of peripheral regulation by a distinct (at last identifiable!) population of T-cells is now back in vogue. These T-regulatory (T-reg) cells have an important function in immune homeostasis. T-reg demand our attention as we try to manipulate the molecular biology of immune responses and inflammation to control autoimmune disorders and enhance transplantation efficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
1076-1608
pubmed:author
pubmed:issnType
Print
pubmed:volume
11
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
286-9
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
2005
pubmed:articleTitle
Basic science for the clinician 32: T-cells with regulatory function.
pubmed:affiliation
Pharmaceutical Research Institute/Bristol-Myers Squibb, Princeton, New Jersey 08543-4000, USA. leonard.sigal@bms.com
pubmed:publicationType
Journal Article, Review