rdf:type |
|
lifeskim:mentions |
|
pubmed:issue |
1
|
pubmed:dateCreated |
2005-12-16
|
pubmed:abstractText |
Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription via both ERalpha and ERbeta. We observed significantly lower tumor growth, decreased angiogenesis, and increased apoptotic index in ERalpha- ERbeta+ MDA-MB-231 tumors in resveratrol-treated nude mice compared with controls. In vitro we found a significant increase in apoptosis in resveratrol-treated MDA-MB-231 cells in addition to significantly reduced extracellular levels of VEGF. This study supports the potential use of resveratrol as a chemotherapeutic agent in breast cancers.
|
pubmed:language |
eng
|
pubmed:journal |
|
pubmed:citationSubset |
IM
|
pubmed:chemical |
|
pubmed:status |
MEDLINE
|
pubmed:month |
Jan
|
pubmed:issn |
0304-3835
|
pubmed:author |
|
pubmed:issnType |
Print
|
pubmed:day |
8
|
pubmed:volume |
231
|
pubmed:owner |
NLM
|
pubmed:authorsComplete |
Y
|
pubmed:pagination |
113-22
|
pubmed:dateRevised |
2006-11-15
|
pubmed:meshHeading |
pubmed-meshheading:16356836-Adenocarcinoma,
pubmed-meshheading:16356836-Animals,
pubmed-meshheading:16356836-Anticarcinogenic Agents,
pubmed-meshheading:16356836-Apoptosis,
pubmed-meshheading:16356836-Breast Neoplasms,
pubmed-meshheading:16356836-Estrogen Receptor alpha,
pubmed-meshheading:16356836-Estrogen Receptor beta,
pubmed-meshheading:16356836-Female,
pubmed-meshheading:16356836-Humans,
pubmed-meshheading:16356836-Mice,
pubmed-meshheading:16356836-Mice, Nude,
pubmed-meshheading:16356836-Neovascularization, Pathologic,
pubmed-meshheading:16356836-Stilbenes,
pubmed-meshheading:16356836-Transplantation, Heterologous,
pubmed-meshheading:16356836-Vascular Endothelial Growth Factor A
|
pubmed:year |
2006
|
pubmed:articleTitle |
Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo.
|
pubmed:affiliation |
Division of Gynecologic Oncology, Faculty of Health Sciences, University Hospital, SE-581 85 Linköping, Sweden.
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|