Linked Life Data

16356714

Source:http://linkedlifedata.com/resource/pubmed/id/16356714

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
2006-2-7
pubmed:abstractText
A new series of 3-benzyl-2-substituted quinoxalines have been synthesized by means of microwave enhancement of nucleophilic substitution reaction involving the corresponding 2-chloroquinoxaline analogs and substituted amines or hydrazine. The synthesized compounds were evaluated for their monoamine oxidase A and B inhibitory activity by determination of their IC(50). All the newly synthesized compounds showed more selective inhibitory activity toward MAO-A than MAO-B. In addition, the acute toxicity of the synthesized compounds was determined. This work may be a fruitful matrix of the synthesis of a new series of novel MAO-A inhibitors with good safety margins.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0960-894X
pubmed:author
pubmed:issnType
Print
pubmed:day
15
pubmed:volume
16
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1753-6
pubmed:meshHeading
pubmed:year
2006
pubmed:articleTitle
Synthesis of 3-benzyl-2-substituted quinoxalines as novel monoamine oxidase A inhibitors.
pubmed:affiliation
Department of Chemistry, Faculty of Science, University of Alexandria, Alexandria 21521, Egypt.
pubmed:publicationType
Journal Article