Source:http://linkedlifedata.com/resource/pubmed/id/16356129
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
11-12
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pubmed:dateCreated |
2005-12-16
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pubmed:abstractText |
Heme oxygenase (HO)-1 is a stress response protein, which confers cytoprotection against oxidative injury and provides a vital function in maintaining tissue homeostasis. Molecular mechanisms involved in the inducible transcription of ho-1 occurring in response to numerous and diverse stressful conditions have remained elusive. Since the discovery of E1 and E2, the two upstream enhancers regulating induction of ho-1 transcription in 1989, there have been many studies dealing with molecular mechanisms involved in enhancing HO-1 expression. In this commentary, recent advances in our understanding of the mechanisms involved in the induction of HO-1 expression in mammalian cells are summarized with some supportive results reported by others. Currently available data indicate that activation of ho-1 transcription involves both the heme (native substrate)-dependent selective alleviation of repressor and the oxidative stress-dependent activation of transcriptional activator. The stress-released free-heme (HO-1 substrate) from hemoproteins involved in causing oxidative stress itself appears to act as a molecular switch controlling the repressor- activator antagonism on the enhancer sequences of ho-1. Thus, induction of HO-1 appears to operate in a manner like a simple feedback loop. dox Signal. 7, 1674-1687.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:issn |
1523-0864
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pubmed:author | |
pubmed:copyrightInfo |
Antioxid. Redox Signal. 7, 1674-1687.
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pubmed:issnType |
Print
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pubmed:volume |
7
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1674-87
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16356129-Animals,
pubmed-meshheading:16356129-Gene Expression Regulation,
pubmed-meshheading:16356129-Heme,
pubmed-meshheading:16356129-Heme Oxygenase-1,
pubmed-meshheading:16356129-Humans,
pubmed-meshheading:16356129-NF-E2-Related Factor 2,
pubmed-meshheading:16356129-Nitrogen,
pubmed-meshheading:16356129-Oxidative Stress
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pubmed:articleTitle |
Molecular mechanisms involved in enhancing HO-1 expression: de-repression by heme and activation by Nrf2, the "one-two" punch.
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pubmed:affiliation |
Department of Pharmacology and Toxicology, College of Medicine, Inha University, Incheon, South Korea.
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pubmed:publicationType |
Journal Article,
Review,
Research Support, Non-U.S. Gov't
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