Linked Life Data

16354923

Source:http://linkedlifedata.com/resource/pubmed/id/16354923

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
50
pubmed:dateCreated
2005-12-15
pubmed:abstractText
Caspase-1 plays a role in the pathogenesis of a variety of neurological diseases. Caspase-1 activation is an early event in models of Huntington's disease (HD). However, mechanisms regulating the activation of this apical caspase in cell death are not known. Receptor interacting protein-2 (Rip2) and caspase recruitment domain (CARD) only protein (Cop) are two CARD proteins with significant homology to the caspase-1 CARD and modulate caspase-1 activation in inflammation. Rip2 is a caspase-1 activator, and Cop is a caspase-1 inhibitor. We demonstrate in models of HD that caspase-1 activation results from dysregulation of caspase-1 activation pathways. Associated with disease progression, we detect elevation of the caspase-1 activator Rip2 and reduction of the caspase-1 inhibitor Cop. Knocking down endogenous Rip2/Cop respectively results in reduced/increased sensitivity to neurotoxic stimuli. Our data provide evidence that caspase-1-mediated cell death is regulated, at least in part, by the balance of Rip2 and Cop, and alterations of this balance may contribute to aberrant caspase-1-mediated pathogenesis in Huntington's disease.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Dec
pubmed:issn
1529-2401
pubmed:author
pubmed:issnType
Electronic
pubmed:day
14
pubmed:volume
25
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
11645-54
pubmed:dateRevised
2009-11-19
pubmed:meshHeading
pubmed-meshheading:16354923-Animals, pubmed-meshheading:16354923-Carrier Proteins, pubmed-meshheading:16354923-Caspase 1, pubmed-meshheading:16354923-Cell Death, pubmed-meshheading:16354923-Cells, Cultured, pubmed-meshheading:16354923-Enzyme Activation, pubmed-meshheading:16354923-HeLa Cells, pubmed-meshheading:16354923-Humans, pubmed-meshheading:16354923-Huntington Disease, pubmed-meshheading:16354923-Mice, pubmed-meshheading:16354923-Neurons, pubmed-meshheading:16354923-Protein-Serine-Threonine Kinases, pubmed-meshheading:16354923-Receptor-Interacting Protein Serine-Threonine Kinase 2, pubmed-meshheading:16354923-Receptor-Interacting Protein Serine-Threonine Kinases, pubmed-meshheading:16354923-Stem Cells, pubmed-meshheading:16354923-Tumor Necrosis Factor Receptor-Associated Peptides and...
pubmed:year
2005
pubmed:articleTitle
Dysregulation of receptor interacting protein-2 and caspase recruitment domain only protein mediates aberrant caspase-1 activation in Huntington's disease.
pubmed:affiliation
Department of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't, Research Support, N.I.H., Extramural