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rdf:type |
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lifeskim:mentions |
umls-concept:C0017287,
umls-concept:C0020202,
umls-concept:C0021149,
umls-concept:C0303920,
umls-concept:C0314603,
umls-concept:C0444498,
umls-concept:C0487602,
umls-concept:C1332080,
umls-concept:C1332942,
umls-concept:C1441616,
umls-concept:C1521733,
umls-concept:C1707520
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|
pubmed:issue |
5
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|
pubmed:dateCreated |
2005-12-14
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|
pubmed:abstractText |
Anaplastic large cell lymphoma (ALCL) comprises 10-15% of childhood non-Hodgkin lymphomas (NHL). Systemic ALCL is highly associated with anaplastic lymphoma kinase (ALK) gene translocations with over-expression of ALK protein. We studied ALK rearrangements using fluorescence in situ hybridisation (FISH) and ALK immunohistochemical staining in 43 paediatric systemic ALCLs. FISH (performed on 35 cases) identified a translocation in 29 cases (83%). Immunohistochemistry identified ALK over-expression in 42/43 cases (97%) with the single ALK-negative case demonstrating an ALK rearrangement by FISH, indicating 100% incidence of ALK translocations.
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pubmed:language |
eng
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pubmed:journal |
|
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0007-1048
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pubmed:author |
|
|
pubmed:issnType |
Print
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pubmed:volume |
131
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
624-7
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:16351638-Adolescent,
pubmed-meshheading:16351638-Antigens, CD,
pubmed-meshheading:16351638-Chromosomes, Human, Pair 2,
pubmed-meshheading:16351638-Chromosomes, Human, Pair 5,
pubmed-meshheading:16351638-Female,
pubmed-meshheading:16351638-Gene Rearrangement,
pubmed-meshheading:16351638-Humans,
pubmed-meshheading:16351638-Immunohistochemistry,
pubmed-meshheading:16351638-Immunophenotyping,
pubmed-meshheading:16351638-In Situ Hybridization, Fluorescence,
pubmed-meshheading:16351638-Lymphoma, Large B-Cell, Diffuse,
pubmed-meshheading:16351638-Male,
pubmed-meshheading:16351638-Nuclear Proteins,
pubmed-meshheading:16351638-Protein-Tyrosine Kinases,
pubmed-meshheading:16351638-Receptor Protein-Tyrosine Kinases,
pubmed-meshheading:16351638-Translocation, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Childhood anaplastic large cell lymphoma has a high incidence of ALK gene rearrangement as determined by immunohistochemical staining and fluorescent in situ hybridisation: a genetic and pathological correlation.
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pubmed:affiliation |
Department of Pathology, University of Utah Health Sciences and ARUP Institute, Salt Lake City, UT 84132, USA. sherrie.perkins@hsc.utah.edu
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't,
Research Support, N.I.H., Extramural
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