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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2005-12-13
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pubmed:abstractText |
The authors report two cases of catechol-O-methyltransferase (COMT) inhibitor-induced asymptomatic hepatic dysfunction in women with Parkinson disease. The patients were genotyped for the UDP-glucuronosyltransferase (UGT) 1A9 gene (which encodes the main COMT inhibitor-metabolizing enzyme), and found to carry mutations leading to defective glucuronidation activity. This suggests that UGT1A9 poor metabolizer genotype(s) may be a predisposing factor for COMT inhibitor-induced hepatotoxicity.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antiparkinson Agents,
http://linkedlifedata.com/resource/pubmed/chemical/Benzophenones,
http://linkedlifedata.com/resource/pubmed/chemical/Catechol O-Methyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Catechols,
http://linkedlifedata.com/resource/pubmed/chemical/Enzyme Inhibitors,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronic Acids,
http://linkedlifedata.com/resource/pubmed/chemical/Glucuronosyltransferase,
http://linkedlifedata.com/resource/pubmed/chemical/Nitriles,
http://linkedlifedata.com/resource/pubmed/chemical/Nitrophenols,
http://linkedlifedata.com/resource/pubmed/chemical/UDP-glucuronosyltransferase 1A9,
http://linkedlifedata.com/resource/pubmed/chemical/entacapone,
http://linkedlifedata.com/resource/pubmed/chemical/tolcapone
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
1526-632X
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pubmed:author |
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pubmed:issnType |
Electronic
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pubmed:day |
13
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pubmed:volume |
65
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1820-2
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pubmed:dateRevised |
2009-11-19
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pubmed:meshHeading |
pubmed-meshheading:16344532-Adult,
pubmed-meshheading:16344532-Aged,
pubmed-meshheading:16344532-Antiparkinson Agents,
pubmed-meshheading:16344532-Benzophenones,
pubmed-meshheading:16344532-Catechol O-Methyltransferase,
pubmed-meshheading:16344532-Catechols,
pubmed-meshheading:16344532-DNA Mutational Analysis,
pubmed-meshheading:16344532-Drug-Induced Liver Injury,
pubmed-meshheading:16344532-Enzyme Inhibitors,
pubmed-meshheading:16344532-Female,
pubmed-meshheading:16344532-Genotype,
pubmed-meshheading:16344532-Glucuronic Acids,
pubmed-meshheading:16344532-Glucuronosyltransferase,
pubmed-meshheading:16344532-Humans,
pubmed-meshheading:16344532-Liver,
pubmed-meshheading:16344532-Liver Diseases,
pubmed-meshheading:16344532-Middle Aged,
pubmed-meshheading:16344532-Mutation,
pubmed-meshheading:16344532-Nitriles,
pubmed-meshheading:16344532-Nitrophenols,
pubmed-meshheading:16344532-Parkinson Disease,
pubmed-meshheading:16344532-Polymorphism, Genetic
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pubmed:year |
2005
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pubmed:articleTitle |
Two patients with COMT inhibitor-induced hepatic dysfunction and UGT1A9 genetic polymorphism.
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pubmed:affiliation |
Department of Clinical Medicine, University of Piemonte Orientale Amedeo Avogadro, Salvatore Maugeri Foundation, Scientific Institute of Veruno, Novara, Italy.
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pubmed:publicationType |
Journal Article,
Case Reports
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