Source:http://linkedlifedata.com/resource/pubmed/id/16343737
Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions |
umls-concept:C0017262,
umls-concept:C0017471,
umls-concept:C0032214,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0035820,
umls-concept:C0162638,
umls-concept:C0185117,
umls-concept:C0221908,
umls-concept:C0600138,
umls-concept:C0763658,
umls-concept:C0851285,
umls-concept:C1332414,
umls-concept:C1332415,
umls-concept:C1511572,
umls-concept:C1531411,
umls-concept:C1545588,
umls-concept:C2911684
|
| pubmed:issue |
1-2
|
| pubmed:dateCreated |
2006-1-9
|
| pubmed:abstractText |
The inhibitor of apoptosis proteins, c-IAP1 and c-IAP2, are highly expressed in rat testis and potentially play a regulatory role in testicular apoptosis. To better understand their functions during spermatogenesis, we have analyzed their spatio-temporal distribution in rat testis, how their expression is controlled by the paracrine stem-cell factor (SCF) and how they affect Fas-mediated apoptosis. Both c-IAP1 and c-IAP2 showed cycles of transcriptional expression, throughout the seminiferous epithelial cycle. c-IAP1 protein showed a diffuse nuclear distribution in type B spermatogonia, preleptotene, leptotene, and zygotene spermatocytes. In pachytene spermatocytes, c-IAP1 colocalized with SUMO-1 in the XY-body. c-IAP2 protein was cytoplasmic in spermatocytes, from stage VI pachytene onwards, round spermatids, elongated spermatids and Leydig cells. Its expression was upregulated by SCF. Inhibition of IAP activity resulted in a greater sensitivity of germ cells to Fas-mediated apoptosis. These results suggest an important role for IAPs in the regulation of spermatogenic apoptosis.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Dec
|
| pubmed:issn |
0303-7207
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:day |
21
|
| pubmed:volume |
245
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
111-20
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:16343737-Animals,
pubmed-meshheading:16343737-Antigens, CD95,
pubmed-meshheading:16343737-Apoptosis,
pubmed-meshheading:16343737-Caspases,
pubmed-meshheading:16343737-Cell Cycle,
pubmed-meshheading:16343737-Enzyme Activation,
pubmed-meshheading:16343737-Gene Expression Regulation,
pubmed-meshheading:16343737-Immunohistochemistry,
pubmed-meshheading:16343737-Inhibitor of Apoptosis Proteins,
pubmed-meshheading:16343737-Male,
pubmed-meshheading:16343737-Rats,
pubmed-meshheading:16343737-Rats, Sprague-Dawley,
pubmed-meshheading:16343737-Seminiferous Epithelium,
pubmed-meshheading:16343737-Spermatogenesis,
pubmed-meshheading:16343737-Spermatozoa,
pubmed-meshheading:16343737-Stem Cell Factor,
pubmed-meshheading:16343737-Testis,
pubmed-meshheading:16343737-Up-Regulation
|
| pubmed:year |
2005
|
| pubmed:articleTitle |
The regulated expression of c-IAP1 and c-IAP2 during the rat seminiferous epithelial cycle plays a role in the protection of germ cells from Fas-mediated apoptosis.
|
| pubmed:affiliation |
Department of Physiology and Pediatrics, University of Turku, Kiinamyllynkatu 10, Turku 20520, Finland. yanwan@utu.fi
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|