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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
11
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pubmed:dateCreated |
2006-2-20
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pubmed:abstractText |
Forty-five GM1-binding peptides were identified using phage-displayed peptides libraries of random peptides. Most have a motif containing a hydrophobic amino acid followed by a serine (S). Based on a GM1-binding assays, two of these GM1-binding peptides (named 15 and 40) were chosen to investigate its immunostimulatory properties when chemically coupled to antigens. Mice intra-nasally (i.n.) vaccinated with some of these complexes developed a better local and systemic antibody response than mice i.n. vaccinated with the respective uncoupled antigens. The efficiency of the complex GM1-binding peptide-antigen strongly depends on the composition and structure of both of the components of the complex.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Adjuvants, Immunologic,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antibodies, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Bacterial,
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Viral,
http://linkedlifedata.com/resource/pubmed/chemical/G(M1) Ganglioside,
http://linkedlifedata.com/resource/pubmed/chemical/Hemagglutinin Glycoproteins...,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin A,
http://linkedlifedata.com/resource/pubmed/chemical/Immunoglobulin G,
http://linkedlifedata.com/resource/pubmed/chemical/Influenza Vaccines,
http://linkedlifedata.com/resource/pubmed/chemical/Neuraminidase,
http://linkedlifedata.com/resource/pubmed/chemical/Peptide Library,
http://linkedlifedata.com/resource/pubmed/chemical/Peptides
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0264-410X
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
10
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pubmed:volume |
24
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1889-96
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pubmed:meshHeading |
pubmed-meshheading:16343699-Adjuvants, Immunologic,
pubmed-meshheading:16343699-Administration, Intranasal,
pubmed-meshheading:16343699-Animals,
pubmed-meshheading:16343699-Antibodies, Bacterial,
pubmed-meshheading:16343699-Antibodies, Viral,
pubmed-meshheading:16343699-Antigens, Bacterial,
pubmed-meshheading:16343699-Antigens, Viral,
pubmed-meshheading:16343699-Bronchoalveolar Lavage Fluid,
pubmed-meshheading:16343699-Cell Wall,
pubmed-meshheading:16343699-Enzyme-Linked Immunosorbent Assay,
pubmed-meshheading:16343699-G(M1) Ganglioside,
pubmed-meshheading:16343699-Hemagglutinin Glycoproteins, Influenza Virus,
pubmed-meshheading:16343699-Immunoglobulin A,
pubmed-meshheading:16343699-Immunoglobulin G,
pubmed-meshheading:16343699-Influenza Vaccines,
pubmed-meshheading:16343699-Mice,
pubmed-meshheading:16343699-Mice, Inbred BALB C,
pubmed-meshheading:16343699-Neuraminidase,
pubmed-meshheading:16343699-Peptide Library,
pubmed-meshheading:16343699-Peptides,
pubmed-meshheading:16343699-Protein Binding,
pubmed-meshheading:16343699-Streptococcus pneumoniae
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pubmed:year |
2006
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pubmed:articleTitle |
Ganglioside GM1-binding peptides as adjuvants of antigens inoculated by the intranasal route.
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pubmed:affiliation |
Instituto de Investigaciones Biomédicas, Fundación Pablo Cassará, Saladillo 2452, Buenos Aires C1440FFX, Argentina.
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pubmed:publicationType |
Journal Article
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