Source:http://linkedlifedata.com/resource/pubmed/id/16343437
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
4
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pubmed:dateCreated |
2005-12-19
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pubmed:abstractText |
We have identified an alternative splicing variant in the Cdc42-interacting protein 4 (CIP4) gene in patients with renal cell carcinoma (RCC); almost 50% of the RCCs examined showed an aberrant splicing event in reverse transcription-PCR and the insertion of 19 nucleotides derived from intron9 based on a sequence analysis. This variant (CIP4-V) encodes a premature stop codon, resulting in the loss of a tyrosine phosphorylation site, the Cdc42 binding domain, and the SH3 domain. In this report, we show that overexpression of CIP4-V causes the formation of ubiquitinated aggresomes and a loss of cell-cell adhesion. We determined that CIP4-V increased the beta-catenin tyrosine phosphorylation levels that mediate Fer/Fyn tyrosine kinases and induced beta-catenin mistrafficking from cell membrane to cytoplasmic aggresome. These results indicate that CIP4 is critical for beta-catenin-mediated cell-cell adhesion and may be an important aspect of its functional contribution to RCC, especially with regard to metastasis and invasiveness.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Recombinant,
http://linkedlifedata.com/resource/pubmed/chemical/Microtubule-Associated Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/TRIP10 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Tumor Markers, Biological,
http://linkedlifedata.com/resource/pubmed/chemical/beta Catenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0006-291X
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:day |
27
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pubmed:volume |
339
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1083-8
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pubmed:dateRevised |
2008-11-21
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pubmed:meshHeading |
pubmed-meshheading:16343437-Carcinoma, Renal Cell,
pubmed-meshheading:16343437-Cell Adhesion,
pubmed-meshheading:16343437-DNA, Recombinant,
pubmed-meshheading:16343437-Genetic Variation,
pubmed-meshheading:16343437-Humans,
pubmed-meshheading:16343437-Kidney Neoplasms,
pubmed-meshheading:16343437-Microtubule-Associated Proteins,
pubmed-meshheading:16343437-Protein Transport,
pubmed-meshheading:16343437-Tumor Cells, Cultured,
pubmed-meshheading:16343437-Tumor Markers, Biological,
pubmed-meshheading:16343437-beta Catenin
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pubmed:year |
2006
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pubmed:articleTitle |
Splicing variant of Cdc42 interacting protein-4 disrupts beta-catenin-mediated cell-cell adhesion: expression and function in renal cell carcinoma.
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pubmed:affiliation |
Tenjin Tsuji Clinic, Fukuoka, Japan. emikot@tt-clinic.com
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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