Source:http://linkedlifedata.com/resource/pubmed/id/16343292
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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
6
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pubmed:dateCreated |
2005-12-13
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pubmed:abstractText |
The objective of this study was to investigate renal function in clinically normal dogs receiving tepoxalin, a nonsteroidal inflammatory drug, either in association with or without an angiotensin-converting enzyme inhibitor (ACEI). Ten adult female Beagle dogs were used in the three phases of the study. The dogs were administered the drugs once daily for 7 days (experiment 1: placebo/tepoxalin/tepoxalin and benazepril; experiment 2: enalapril/tepoxalin and enalapril) or for 28 days (experiment 3: tepoxalin and benazepril together). Renal function was assessed by measurement of glomerular filtration rate (GFR) by renal scintigraphy [(renal uptake of 99mTc-diethylenetriaminepentacetic acid (DTPA)] and plasma clearance of 99mTc-DTPA. Compared with the placebo group, renal uptake and plasma clearance of 99mTc-DTPA were not significantly modified after a 7-day period of treatment with tepoxalin or enalapril alone, tepoxalin and benazepril or tepoxalin and enalapril together. No significant change was obtained in GFR after a 28-day period of dosing with tepoxalin and benazepril together. Therefore, it was concluded that tepoxalin did not alter renal function in healthy Beagle dogs receiving ACEI.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Angiotensin-Converting Enzyme...,
http://linkedlifedata.com/resource/pubmed/chemical/Anti-Inflammatory Agents...,
http://linkedlifedata.com/resource/pubmed/chemical/Benzazepines,
http://linkedlifedata.com/resource/pubmed/chemical/Enalapril,
http://linkedlifedata.com/resource/pubmed/chemical/Pyrazoles,
http://linkedlifedata.com/resource/pubmed/chemical/Radiopharmaceuticals,
http://linkedlifedata.com/resource/pubmed/chemical/Technetium Tc 99m Pentetate,
http://linkedlifedata.com/resource/pubmed/chemical/benazepril,
http://linkedlifedata.com/resource/pubmed/chemical/tepoxalin
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pubmed:status |
MEDLINE
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pubmed:month |
Dec
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pubmed:issn |
0140-7783
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
28
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
581-6
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16343292-Angiotensin-Converting Enzyme Inhibitors,
pubmed-meshheading:16343292-Animals,
pubmed-meshheading:16343292-Anti-Inflammatory Agents, Non-Steroidal,
pubmed-meshheading:16343292-Benzazepines,
pubmed-meshheading:16343292-Dogs,
pubmed-meshheading:16343292-Drug Therapy, Combination,
pubmed-meshheading:16343292-Enalapril,
pubmed-meshheading:16343292-Female,
pubmed-meshheading:16343292-Glomerular Filtration Rate,
pubmed-meshheading:16343292-Kidney,
pubmed-meshheading:16343292-Kidney Function Tests,
pubmed-meshheading:16343292-Pyrazoles,
pubmed-meshheading:16343292-Radiopharmaceuticals,
pubmed-meshheading:16343292-Technetium Tc 99m Pentetate
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pubmed:year |
2005
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pubmed:articleTitle |
Effect of tepoxalin on renal function in healthy dogs receiving an angiotensin-converting enzyme inhibitor.
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pubmed:affiliation |
Unité de Physiopathologie Animale et Pharmacologie Fonctionnelle, UPSP, ENV Nantes, Nantes Cedex, France.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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