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rdf:type |
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lifeskim:mentions |
umls-concept:C0010453,
umls-concept:C0015350,
umls-concept:C0017262,
umls-concept:C0034693,
umls-concept:C0034721,
umls-concept:C0068450,
umls-concept:C0185117,
umls-concept:C0205263,
umls-concept:C0205369,
umls-concept:C0547047,
umls-concept:C0919432,
umls-concept:C1704256,
umls-concept:C1999216,
umls-concept:C2340138,
umls-concept:C2911684
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pubmed:issue |
1
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pubmed:dateCreated |
2006-2-9
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pubmed:abstractText |
During the process of liver fibrogenesis, transforming growth factor-beta (TGF-beta) plays an essential role in modulating extracellular matrix (ECM) gene expression, and a growing body of evidence suggests that this is a Smad3-dependent process in the activated hepatic stellate cells (HSCs). Naringenin showed a significantly protective effect on experimental rat liver fibrosis, in our efforts to elucidate its antifibrosis molecular mechanisms and to find a novel target based on Smad3 signaling for challenging fibrosis diseases.
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Collagen Type I,
http://linkedlifedata.com/resource/pubmed/chemical/Estrogen Antagonists,
http://linkedlifedata.com/resource/pubmed/chemical/Fibronectins,
http://linkedlifedata.com/resource/pubmed/chemical/Flavanones,
http://linkedlifedata.com/resource/pubmed/chemical/Madh3 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Plasminogen Activator Inhibitor 1,
http://linkedlifedata.com/resource/pubmed/chemical/RNA,
http://linkedlifedata.com/resource/pubmed/chemical/RNA, Messenger,
http://linkedlifedata.com/resource/pubmed/chemical/Smad3 Protein,
http://linkedlifedata.com/resource/pubmed/chemical/Tgfb1 protein, rat,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta,
http://linkedlifedata.com/resource/pubmed/chemical/Transforming Growth Factor beta1,
http://linkedlifedata.com/resource/pubmed/chemical/naringenin
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pubmed:status |
MEDLINE
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pubmed:month |
Jan
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pubmed:issn |
0724-8741
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
23
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
82-9
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:16341574-Animals,
pubmed-meshheading:16341574-Blotting, Western,
pubmed-meshheading:16341574-Cell Survival,
pubmed-meshheading:16341574-Cells, Cultured,
pubmed-meshheading:16341574-Collagen Type I,
pubmed-meshheading:16341574-Estrogen Antagonists,
pubmed-meshheading:16341574-Extracellular Matrix,
pubmed-meshheading:16341574-Fibronectins,
pubmed-meshheading:16341574-Flavanones,
pubmed-meshheading:16341574-Gene Expression Regulation,
pubmed-meshheading:16341574-Liver,
pubmed-meshheading:16341574-Phosphorylation,
pubmed-meshheading:16341574-Plasminogen Activator Inhibitor 1,
pubmed-meshheading:16341574-RNA,
pubmed-meshheading:16341574-RNA, Messenger,
pubmed-meshheading:16341574-Rats,
pubmed-meshheading:16341574-Reverse Transcriptase Polymerase Chain Reaction,
pubmed-meshheading:16341574-Smad3 Protein,
pubmed-meshheading:16341574-Transforming Growth Factor beta,
pubmed-meshheading:16341574-Transforming Growth Factor beta1
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pubmed:year |
2006
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pubmed:articleTitle |
Smad3 specific inhibitor, naringenin, decreases the expression of extracellular matrix induced by TGF-beta1 in cultured rat hepatic stellate cells.
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pubmed:affiliation |
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing, 100101, China.
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pubmed:publicationType |
Journal Article
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